ArticleNature communications2018
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
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Who cites it
98 citing papers in PubMed, 143 citations in OpenAlex.
- Two dipeptide repeat proteins are produced from mammalian telomeric RNA previously thought to be a long non-coding RNA.RNA biology · 2026Review
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- Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.Nucleic acids research · 2026Article
- RAN Translation-Coupled Decay of theInternational journal of molecular sciences · 2026Article
- Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.bioRxiv : the preprint server for biology · 2026Article
- Upstream non-AUG initiation and ribosomal -1 frameshifting in ATXN8OS CTA/CTG repeat-associated translation.Nucleic acids research · 2026Article
- Coordinated translation initiation determines -1 programmed ribosomal frameshifting efficiency of chromosomal genes to impact on cell fitness.The FEBS journal · 2026Article
- Blocking RAN translation without altering repeat RNAs rescuesScience (New York, N.Y.) · 2026Article
- A distal promoter and aberrant splicing enable canonical translation of out-of-frame proteins in Huntington's disease.bioRxiv : the preprint server for biology · 2025Article
- Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.Nucleic acids research · 2025Article
- Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.Nucleic acids research · 2024Article
- CriticalNAR genomics and bioinformatics · 2024Article
- Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.EMBO reports · 2024Article
- Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis.Heliyon · 2024Article
- dCas13-mediated translational repression for accurate gene silencing in mammalian cells.Nature communications · 2024Article
- Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo.Gene therapy · 2024Article
- The molecular basis of translation initiation and its regulation in eukaryotes.Nature reviews. Molecular cell biology · 2024Review
- CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.Molecular cell · 2024Article
- Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors.Scientific reports · 2023Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 5 institutions in 2 countries.
Ricardos TabetDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Laure SchaefferArchitecture et Réactivité de l'ARN, UPR 9002, Université de Strasbourg, CNRS, F-67000, Strasbourg, France.
Fernande FreyermuthDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Melanie JambeauDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Michael WorkmanDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Chao-Zong LeeDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Chun-Chia LinDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Jie JiangLudwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.
Karen Jansen-WestDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Hussein Abou-HamdanTherapeutic Innovation Laboratory (UMR 7200), Faculty of Pharmacy, CNRS/University of Strasbourg, 67401, Illkirch, Cedex, France.
Laurent DésaubryTherapeutic Innovation Laboratory (UMR 7200), Faculty of Pharmacy, CNRS/University of Strasbourg, 67401, Illkirch, Cedex, France.
Tania GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Franck MartinArchitecture et Réactivité de l'ARN, UPR 9002, Université de Strasbourg, CNRS, F-67000, Strasbourg, France. f.martin@ibmc-cnrs.unistra.fr.ORCID http://orcid.org/0000-0001-9724-4025
Clotilde Lagier-TourenneDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. clagier-tourenne@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-3058-8322
Broad Institute · USCentre National de la Recherche Scientifique · FRHarvard University · USJacksonville College · USUniversity of California San Diego · US
Funding
Using RNA signatures for therapy development in neurodegeneration due to C9orf72 expansionsR01NS087227 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LAGIER-TOURENNE, CLOTILDE · 2014 to 2018
$1.5MNINDS NIH HHS R01 NS087227
Abstract
Expansion of G
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinCell LineDipeptidesEukaryotic Initiation Factor-4FFrameshifting, RibosomalFrontotemporal DementiaHEK293 CellsHumansMicrosatellite RepeatsOligonucleotides, AntisenseOpen Reading FramesPeptide Chain Initiation, TranslationalRibosomesRNA, AntisenseRNA, Transfer, MetC9orf72 ProteinC9orf72 protein, humanDipeptidesEukaryotic Initiation Factor-4FOligonucleotides, AntisenseRNA, AntisenseRNA, Transfer, Met
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.