ArticleNature communications2018
Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed.
- On-Demand Photoprotection by UV-Transparent Small Molecules via Aggregation-Induced Absorption: The Origin and Modern Application.ACS central science · 2026Article
- Proto-Biosignatures and Planetary Geochemical Metabolism: A Thermodynamic Screening Model of Prebiotic Geochemical Organization.Life (Basel, Switzerland) · 2026Article
- G-quadruplexes self-assembled from nucleotide monomers as stable prepolymer scaffolds in aqueous environments.Scientific reports · 2026Article
- Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification.ACS bio & med chem Au · 2025Article
- The Origin of the Feedstock Molecules for Life on the Hadean Earth.Angewandte Chemie (International ed. in English) · 2025Article
- A scope of prebiotic neat reaction conditions and the mechanism of urea-assisted phosphorylations of alcohols.Nature communications · 2025Article
- High-Yield Prebiotic Polymerization of 2',3'-Cyclic Nucleotides under Wet-Dry Cycling.ACS central science · 2025Article
- Review
- Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem : a European journal of chemical biology · 2025Review
- Light-Assisted Formation of Nucleosides and Nucleotides from Formamide in the Presence of Cerium Phosphate.Life (Basel, Switzerland) · 2024Article
- Microfluidics-Based Drying-Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions.Life (Basel, Switzerland) · 2024Article
- A Prebiotic Precursor to Life's Phosphate Transfer System with an ATP Analog and Histidyl Peptide Organocatalysts.Journal of the American Chemical Society · 2024Article
- Nonequilibrium Wet-Dry Cycling Acts as a Catalyst for Chemical Reactions.The journal of physical chemistry. B · 2024Article
- Sustained wet-dry cycling on early Mars.Nature · 2023Article
- Volcanic Island lightning prebiotic chemistry and the origin of life in the early Hadean eon.Nature communications · 2023Article
- Dynamic Environmental Conditions Affect the Composition of a Model Prebiotic Reaction Network.Journal of the American Chemical Society · 2023Article
- Confinement effect on hydrolysis in small lipid vesicles.Chemical science · 2023Article
- Self-Similar Patterns from Abiotic Decarboxylation Metabolism through Chemically Oscillating Reactions: A Prebiotic Model for the Origin of Life.Life (Basel, Switzerland) · 2023Article
- Setting the geological scene for the origin of life and continuing open questions about its emergence.Frontiers in astronomy and space sciences · 2023Article
- Prebiotic chemical refugia: multifaceted scenario for the formation of biomolecules in primitive Earth.Theory in biosciences = Theorie in den Biowissenschaften · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet-dry cycles. These conditions might have allowed for the formation of (self)-replicating RNA as the fundamental biopolymer during chemical evolution. The question of how a complex multistep chemical synthesis of RNA building blocks was possible in such an environment remains unanswered. Here we report that geothermal fields could provide the right setup for establishing wet-dry cycles that allow for the synthesis of RNA nucleosides by continuous synthesis. Our model provides both the canonical and many ubiquitous non-canonical purine nucleosides in parallel by simple changes of physical parameters such as temperature, pH and concentration. The data show that modified nucleosides were potentially formed as competitor molecules. They could in this sense be considered as molecular fossils.
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