Evidence map›Paper›PMID 29323110›Full record

ArticleNature communications2018

Free choice shapes normalized value signals in medial orbitofrontal cortex.

Hiroshi Yamada, Kenway Louie, Agnieszka Tymula, Paul W Glimcher

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  4. eLife · 2024
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  10. Review
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  13. Divisive normalization is an efficient code for multivariate Pareto-distributed environments.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hiroshi YamadaCenter for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York, 10003, USA. h-yamada@md.tsukuba.ac.jp.
Kenway LouieCenter for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York, 10003, USA.
Agnieszka TymulaCenter for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York, 10003, USA.
Paul W GlimcherCenter for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York, 10003, USA.

Funding

Vision Core Grant- Design and Fabrication ModuleP30EY013079 · NEI · NEW YORK UNIVERSITY · PI MOVSHON, J ANTHONY · 2000 to 2025
$14.2M
Adaptation in decision circuits: temporal history and the efficiency of choiceR01MH104251 · NIMH · NEW YORK UNIVERSITY · PI LOUIE, KENWAY · 2015 to 2019
$1.9M
Neural Mechanisms of Cost and Benefit Integration During Decision-MakingR01DA038063 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GLIMCHER, PAUL W · 2014 to 2018
$1.7M
NEI NIH HHS P30 EY013079NIDA NIH HHS R01 DA038063NIMH NIH HHS R01 MH104251
6 · The paper itself

Abstract

Normalization is a common cortical computation widely observed in sensory perception, but its importance in perception of reward value and decision making remains largely unknown. We examined (1) whether normalized value signals occur in the orbitofrontal cortex (OFC) and (2) whether changes in behavioral task context influence the normalized representation of value. We record medial OFC (mOFC) single neuron activity in awake-behaving monkeys during a reward-guided lottery task. mOFC neurons signal the relative values of options via a divisive normalization function when animals freely choose between alternatives. The normalization model, however, performed poorly in a variant of the task where only one of the two possible choice options yields a reward and the other was certain not to yield a reward (so called: "forced choice"). The existence of such context-specific value normalization may suggest that the mOFC contributes valuation signals critical for economic decision making when meaningful alternative options are available.

Indexed as

Models, NeurologicalAnimalsChoice BehaviorElectrophysiologyMacaca mulattaNeuronsPhotic StimulationPrefrontal CortexReward

Identifiers

PMID29323110
PMCPMC5764979

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.