ArticleNeural regeneration research2017
Electroacupuncture improves neurovascular unit reconstruction by promoting collateral circulation and angiogenesis.
Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review.Frontiers in neurology · 2025Pooled it
- Optimal acupuncture methods for lower limb motor dysfunction after stroke: a systematic review and network meta-analysis.Frontiers in neurology · 2024Pooled it
- Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review.Neural plasticity · 2022Pooled it
- Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke.CNS neuroscience & therapeutics · 2026Review
- Heterogeneity of Microglia in Ischemic Stroke from the Perspective of Single-Cell RNA Sequencing: Subset Characteristics, Mechanisms and Therapeutic Potential.Journal of central nervous system disease · 2026Review
- Electroacupuncture Attenuates Nerve Injury in Cerebral Small Vessel Disease by Protecting the Neurovascular Units.Neurochemical research · 2025Article
- Perineural Electrical Dry Needling and Neural Mobilization for Chemotherapy-Induced Peripheral Neuropathy: Case Report.Journal of clinical medicine · 2025Article
- Electroacupuncture pretreatment inhibits ferroptosis and inflammation after middle cerebral artery occlusion in rats by activating Nrf2.Histology and histopathology · 2025Article
- Acupuncture for Ischemic Stroke: A Critical Evaluation of Biological Mechanisms and Methodological Challenges.International journal of general medicine · 2025Review
- Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications.Frontiers in aging neuroscience · 2025Review
- Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7.Chinese journal of integrative medicine · 2024Article
- Mobilizing endogenous neuroprotection: the mechanism of the protective effect of acupuncture on the brain after stroke.Frontiers in neuroscience · 2024Review
- Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling.CNS neuroscience & therapeutics · 2023Article
- Nucleic acid drug vectors for diagnosis and treatment of brain diseases.Signal transduction and targeted therapy · 2023Review
- Electroacupuncture inhibits the expression of HMGB1/RAGE and alleviates injury to the primary motor cortex in rats with cerebral ischemia.Translational neuroscience · 2023Article
- Combination of stem cell therapy and acupuncture to treat ischemic stroke: a prospective review.Stem cell research & therapy · 2022Review
- Cerebral Blood Flow Velocity Modulation and Clinical Efficacy of Acupuncture for Posterior Circulation Infarction Vertigo: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Effect of electroacupuncture and scalp acupuncture combined with language rehabilitation training on cognitive and speech functions of aphasia patients after craniocerebral injury.American journal of translational research · 2022Article
- Article
- Potential mechanisms of acupuncture in enhancing cerebral perfusion of ischemic stroke.Frontiers in neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acupuncture at Shuigou (GV26) shows good clinical efficacy for treating stroke, but its mechanism remains poorly understood. In this study, a cerebral infarction model of ischemia/reperfusion injury received electroacupuncture at GV26 (15 Hz and 1 mA, continuous wave [biphasic pulses], for 5 minutes). Electroacupuncture effectively promoted regional cerebral blood flow on the infarct and non-infarct sides, increased infarct lesions, lectin, and number of blood vessels, upregulated von Willebrand factor and cell proliferation marker Ki67 expression, and diminished neurological severity score. These findings confirm that electroacupuncture at GV26 promotes establishment of collateral circulation and angiogenesis, and improves neurological function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.