Evidence map›Paper›PMID 29322860›Full record

Observational studyJournal of child neurology2018

Antenatal and Neonatal Antecedents of Executive Dysfunctions in Extremely Preterm Children.

Alan Leviton, Robert M Joseph, Elizabeth N Allred, T Michael O'Shea, H Gerry Taylor, Karl K C Kuban

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of child neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05368077 (Brain Changes in Pediatric Obstructive Sleep Apnea), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05368077 nacompletednot on this mapstarted 2022, after this paper: background citation

Brain Changes in Pediatric Obstructive Sleep Apnea

TypeinterventionalSponsorUniversity of California, Los AngelesRan2022 to 2024Enrolled56ConditionsPediatric Obstructive Sleep ApneaArmsAdenotonsillectomy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Alan Leviton1 Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Robert M Joseph2 Boston University School of Medicine, Boston, MA, USA.
Elizabeth N Allred1 Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
T Michael O'Shea3 University of North Carolina School of Medicine, NC, USA.
H Gerry Taylor4 Nationwide Children's Hospital and Ohio State University, Columbus, OH, USA.
Karl K C Kuban5 Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.
Boston Children's Hospital · USBoston Medical Center · USHarvard University · USNationwide Children's Hospital · US

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
The Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9M
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4M
NICHD NIH HHS P30 HD018655NIH HHS UG3 OD023348NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

To find out why children born extremely preterm are at heightened risk of executive dysfunctions, the authors assessed 716 children who were 10 years old born extremely preterm whose IQ was ≥ 70. A working memory dysfunction (n = 169), an inhibition dysfunction (n = 360), a switching dysfunction (355), and all 3 (executive dysfunction; n = 107) were defined on the basis of Z-scores ≤ -1 on the Differential Ability Scales-II Working Memory composite, and/or on the NEPSY-II Inhibition-Inhibition and Inhibition-Switching subtests. All risk profiles include an indicator of socioeconomic disadvantage. The risk profile of each of the 3 individual dysfunctions includes an indicator of the newborn's immaturity, and the risk profiles of the inhibition dysfunction and switching dysfunction also include an indicator of inflammation. Only the switching dysfunction was associated with fetal growth restriction. The risk factors for executive dysfunction can be subsumed under the 4 themes of socioeconomic disadvantage, immaturity/vulnerability, inflammation, and fetal growth restriction.

Indexed as

Executive FunctionChildFetal Growth RetardationFollow-Up StudiesHumansInfant, Extremely PrematureInflammationLearning DisabilitiesNeuropsychological TestsPrevalenceProspective StudiesRisk FactorsSocioeconomic Factorsextremely pretermlearning disabilitiesmathematicsreadingschool performancespecial educational needs

Identifiers

PMID29322860
PMCPMC5807158
OpenAlexW2782769053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.