ArticleHuman brain mapping2018
Abnormal fronto-striatal activation as a marker of threshold and subthreshold Bulimia Nervosa.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Support vector machine-based classification of bulimia nervosa using diffusion tensor imaging.Frontiers in psychiatry · 2025Article
- Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Bulimia Nervosa (BN): A Review and Insight into Potential Mechanisms of Action.Journal of clinical medicine · 2024Review
- Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments.Brain sciences · 2024Review
- Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa.Psychological medicine · 2023Article
- Potential benefits and limitations of machine learning in the field of eating disorders: current research and future directions.Journal of eating disorders · 2022Review
- Prenatal environmental tobacco smoke exposure alters children's cognitive control circuitry: A preliminary study.Environment international · 2021Article
- Machine learning to advance the prediction, prevention and treatment of eating disorders.European eating disorders review : the journal of the Eating Disorders Association · 2021Article
- Control of response interference: caudate nucleus contributes to selective inhibition.Scientific reports · 2020Article
- More stringent criteria are needed for diagnosing internet gaming disorder: Evidence from regional brain features and whole-brain functional connectivity multivariate pattern analyses.Journal of behavioral addictions · 2020Article
- Disturbed Resting-State Whole-Brain Functional Connectivity of Striatal Subregions in Bulimia Nervosa.The international journal of neuropsychopharmacology · 2020Article
- Subcortical Shape Abnormalities in Bulimia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Neuroimaging and eating disorders.Current opinion in psychiatry · 2019Review
- Abnormal structural brain network and hemisphere-specific changes in bulimia nervosa.Translational psychiatry · 2019Article
- Deficient Functioning of Frontostriatal Circuits During the Resolution of Cognitive Conflict in Cannabis-Using Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Cognitive Neuroscience of Eating Disorders.The Psychiatric clinics of North America · 2019Review
- The elusive functional bases of appetite control in the brain.EBioMedicine · 2018Article
- Abnormal fronto-striatal activation as a marker of threshold and subthreshold Bulimia Nervosa.Human brain mapping · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to determine whether functional disturbances in fronto-striatal control circuits characterize adolescents with Bulimia Nervosa (BN) spectrum eating disorders regardless of clinical severity. FMRI was used to assess conflict-related brain activations during performance of a Simon task in two samples of adolescents with BN symptoms compared with healthy adolescents. The BN samples differed in the severity of their clinical presentation, illness duration and age. Multi-voxel pattern analyses (MVPAs) based on machine learning were used to determine whether patterns of fronto-striatal activation characterized adolescents with BN spectrum disorders regardless of clinical severity, and whether accurate classification of less symptomatic adolescents (subthreshold BN; SBN) could be achieved based on patterns of activation in adolescents who met DSM5 criteria for BN. MVPA classification analyses revealed that both BN and SBN adolescents could be accurately discriminated from healthy adolescents based on fronto-striatal activation. Notably, the patterns detected in more severely ill BN compared with healthy adolescents accurately discriminated less symptomatic SBN from healthy adolescents. Deficient activation of fronto-striatal circuits can characterize BN early in its course, when clinical presentations are less severe, perhaps pointing to circuit-based disturbances as useful biomarker or risk factor for the disorder, and a tool for understanding its developmental trajectory, as well as the development of early interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.