Evidence map›Paper›PMID 29322616›Full record

ArticleMagnetic resonance in medicine2018

Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

Ilwoo Park, Peder E Z Larson, Jeremy W Gordon, Lucas Carvajal, Hsin-Yu Chen, Robert Bok, Mark Van Criekinge, Marcus Ferrone, James B Slater, Duan Xu and 4 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07510607 (Assessing Metabolic Changes in Multiple Sclerosis Using Hyper-polarized Carbon 13 MRI), which is not on this map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07510607 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing Metabolic Changes in Multiple Sclerosis Using Hyper-polarized Carbon 13 MRI

TypeinterventionalSponsorAri GreenRan2026 to 2029Enrolled40ConditionsMultiple Sclerosis, RRMS, Relapsing Remitting MSArmsHP 13C pyruvate injection, MRI Scanner
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  3. Review
  4. Review
  5. HyperpolarizedImaging neuroscience (Cambridge, Mass.) · 2026
    Article
  6. Article
  7. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  12. Hyperpolarized MRI theranostics in cancer.Frontiers in oncology · 2025
    Article
  13. Article
  14. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Ilwoo ParkDepartment of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0003-4183-3634
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Robert BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Mark Van CriekingeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Marcus FerroneDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.
James B SlaterDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Susan ChangDepartment of Neurological Surgery, University of California, San Francisco, California, USA.
Sarah J NelsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
University of California, San Francisco · USChonnam National University Hospital · KR

Funding

Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
RESPONSE TO THERAPY FOR PATIENTS WITH GLIOMA USING HYPERPOLARIZED C-13 PYRUVATER21CA170148 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, SARAH J. · 2012 to 2013
$631k
NCI NIH HHS P01 CA118816NCI NIH HHS R21 CA170148NCI NIH HHS T32 CA151022NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB017449
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carbon IsotopesMagnetic Resonance ImagingAdultBrainBrain NeoplasmsEquipment DesignFeasibility StudiesFemaleHumansMaleMiddle AgedNervous System DiseasesNeuroimagingPhantoms, ImagingPyruvic AcidSignal-To-Noise RatioCarbon-13Carbon IsotopesPyruvic Acidbrain tumor patientsdynamic nuclear polarizationhyperpolarized carbon-13 MRI

Identifiers

PMID29322616
PMCPMC5980662
OpenAlexW2783916060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.