ArticleHuman brain mapping2018
Functional connectivity predicts gender: Evidence for gender differences in resting brain connectivity.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 243 citations in OpenAlex.
- Concurrent Supervised-Unsupervised Representative Subspace Clustering (CSU-RSC).bioRxiv : the preprint server for biology · 2026Article
- Functional near-infrared spectroscopy assessment of the brain functional connectivity of sedated patients in the emergency intensive care unit.Scientific reports · 2026Article
- Multi-Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Preliminary Evidence for Changes in Functional Connectivity Associated with Emotional Awareness after Mobile-Based Mindfulness Meditation.Yonsei medical journal · 2026Article
- Altered functional connectivity is associated with Repeatable Battery for the Assessment of Neuropsychological Status across the dementia spectrum.Journal of the International Neuropsychological Society : JINS · 2026Article
- Gender differences in clinical correlates of glucose disturbance in patients with first-episode and drug-naïve major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- Sex differences in human brain dynamics assessed with edge functional connectivity.Brain imaging and behavior · 2026Article
- The progression of sex differences in brain networks across the lifespan.bioRxiv : the preprint server for biology · 2026Article
- High brain network system segregation is differentially linked with cognitive performance across the life span.Network neuroscience (Cambridge, Mass.) · 2026Article
- Study of sex differences in the whole brain white matter using diffusion MRI tractography and suprathreshold fiber cluster statistics.NeuroImage. Clinical · 2026Article
- Sex Classification Based on the Functional Connectivity Patterns of the Language Network: A Resting State fMRI Study.Human brain mapping · 2026Article
- Sex difference in the neural correlates of volitional eyes closing.Scientific reports · 2025Article
- Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Study of Sex Differences in the Whole Brain White Matter Using Diffusion MRI Tractography and Suprathreshold Fiber Cluster Statistics.bioRxiv : the preprint server for biology · 2025Article
- The effects of sex and age on movie-watching functional connectivity and movie clip classification.Brain structure & function · 2025Article
- Residence in Communities With Higher Violent Crimes Associated With Lower Reward-related Brain Function.Biopsychosocial science and medicine · 2025Article
- "Precision Medicine" and the Failed Search for Binary Brain Sex Differences to Address Gender Behavioral Health Disparities.American journal of human biology : the official journal of the Human Biology Council · 2025Review
- Tensor dictionary-based heterogeneous transfer learning to study emotion-related gender differences in brain.Neural networks : the official journal of the International Neural Network Society · 2025Article
- Stimulus Selection Influences Prediction of Individual Phenotypes in Naturalistic Conditions.Human brain mapping · 2025Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevalence of certain forms of psychopathology, such as autism and depression, differs between genders and understanding gender differences of the neurotypical brain may provide insights into risk and protective factors. In recent research, resting state functional magnetic resonance imaging (rfMRI) is widely used to map the inherent functional networks of the brain. Although previous studies have reported gender differences in rfMRI, the robustness of gender differences is not well characterized. In this study, we use a large data set to test whether rfMRI functional connectivity (FC) can be used to predict gender and identify FC features that are most predictive of gender. We utilized rfMRI data from 820 healthy controls from the Human Connectome Project. By applying a predefined functional template and partial least squares regression modeling, we achieved a gender prediction accuracy of 87% when multi-run rfMRI was used. Permutation tests confirmed that gender prediction was reliable ( p<.001). Effects of motion, age, handedness, blood pressure, weight, and brain volume on gender prediction are discussed. Further, we found that FC features within the default mode (DMN), fronto-parietal and sensorimotor networks contributed most to gender prediction. In the DMN, right fusiform gyrus and right ventromedial prefrontal cortex were important contributors. The above regions have been previously implicated in aspects of social functioning and this suggests potential gender differences in social cognition mediated by the DMN. Our findings demonstrate that gender can be reliably predicted using rfMRI data and highlight the importance of controlling for gender in brain imaging studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.