ReviewPediatric nephrology (Berlin, Germany)2018
Combined and sequential liver-kidney transplantation in children.
Review in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Combined Liver-Kidney Transplantation in Pediatric Patients From Colombia: A Case Series.Pediatric transplantation · 2026Article
- Use of En Bloc Kidney Allografts for Pediatric Kidney-Alone and Multiorgan Transplant Recipients in the United States.Pediatric transplantation · 2026Article
- Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience.Life (Basel, Switzerland) · 2024Article
- Evaluation and post-transplant management of children after multi-organ-with-kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2024Review
- Restored glyoxylate metabolism after AGXT gene correction and direct reprogramming of primary hyperoxaluria type 1 fibroblasts.iScience · 2024Article
- Clinical Outcomes and Quality of Life of Patients Receiving Multi-Solid-Organ Transplants in Childhood Are Excellent: Results From a 20-Year Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Short-Term Outcome of Isolated Kidney Transplantation in Children with Autosomal Recessive Polycystic Kidney Disease: A Case Series and Literature Review.Clinics and practice · 2023Article
- A case report of invasive infantile primary hyperoxaluria type 1 and literature review.CEN case reports · 2023Review
- Effect of liver transplantation with primary hyperoxaluria type 1: Five case reports and review of literature.World journal of clinical cases · 2023Article
- Imaging manifestations of Caroli disease with autosomal recessive polycystic kidney disease: a case report and literature review.BMC pregnancy and childbirth · 2021Review
- Combined liver-kidney transplantation for rare diseases.World journal of hepatology · 2020Review
- Combined liver and kidney transplantation in children and long-term outcome.World journal of transplantation · 2020Review
- Deceased vs living donor grafts for pediatric simultaneous liver-kidney transplantation: A single-center experience.Journal of clinical laboratory analysis · 2020Article
- Combined liver-kidney transplant in a 21-month-old child with type 1 primary hyperoxaluria-The perioperative challenges.Indian journal of anaesthesia · 2020Article
- IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection.International journal of molecular sciences · 2020Article
- Occurrence of Portal Hypertension and Its Clinical Course in Patients With Molecularly Confirmed Autosomal Recessive Polycystic Kidney Disease (ARPKD).Frontiers in pediatrics · 2020Article
- Skin microvascular dysfunction as an early cardiovascular marker in primary hyperoxaluria type I.Pediatric nephrology (Berlin, Germany) · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combined and sequential liver-kidney transplantation (CLKT and SLKT) is a definitive treatment in children with end-stage organ failure. There are two major indications: - terminal insufficiency of both organs, or - need for transplanting new liver as a source of lacking enzyme or specific regulator of the immune system in a patient with renal failure. A third (uncommon) option is secondary end-stage renal failure in liver transplant recipients. These three clinical settings use distinct qualification algorithms. The most common indications include primary hyperoxaluria type 1 (PH1) and autosomal recessive polycystic kidney disease (ARPKD), followed by liver diseases associated with occasional kidney failure. Availability of anti-C5a antibody (eculizumab) has limited the validity of CLKT in genetic atypical hemolytic uremic syndrome (aHUS). The liver coming from the same donor as renal graft (in CLKT) is immunologically protective for the kidney and this provides long-term rejection-free follow-up. No such protection is observed in SLKT, when both organs come from different donors, except uncommon cases of living donation of both organs. Overall long-term outcome in CLKT in terms of graft survival is good and not different from isolated liver or kidney transplantation, however patient survival is inferior due to complexity of this procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.