ArticleJournal of ophthalmic inflammation and infection2018
Outcome of polymerase chain reaction (PCR) analysis in 100 suspected cases of infectious uveitis.
Article in Journal of ophthalmic inflammation and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Diagnostic and therapeutic impact of PCR in uveitis: real-world data from intraocular fluid analysis of 45 uveitis patients in a tertiary referral center in Turkey.BMC ophthalmology · 2026Article
- Current perspective on infectious uveitis.Indian journal of ophthalmology · 2026Review
- Quantitative levels of interferon gamma as a biomarker in the aqueous and serum samples of infectious and noninfectious uveitis patients.Journal of ophthalmic inflammation and infection · 2025Article
- Detection of Mycobacterium tuberculosis DNA in intraocular fluid of 11 suspected tuberculous uveitis patients by multiplex PCR.BMC ophthalmology · 2025Article
- Polymerase chain reaction test for diagnosis of infectious uveitis.International journal of retina and vitreous · 2023Article
- A Case of Frosted Branch Angiitis in the Age of Polymerase Chain Reaction: Diagnostic and Therapeutic Considerations.Cureus · 2022Article
- Commentary: Epidemiological study in uveitis - Does it help?Indian journal of ophthalmology · 2022Article
- Ocular Manifestations of Chikungunya Infection: A Systematic Review.Pathogens (Basel, Switzerland) · 2022Review
- The impact of polymerase chain reaction (PCR) on diagnosis and management of infectious uveitis at a tertiary care facility.Journal of ophthalmic inflammation and infection · 2022Article
- Coats-like response in tubercular subretinal abscess masquerading as melanoma as the initial manifestation of miliary tuberculosis.Indian journal of ophthalmology · 2020Article
- Exploration of Anti-infectives From Mangrove-DerivedFrontiers in microbiology · 2020Article
- Performance of 2 Polymerization Protocols Targeting Cloned Toxoplasma Parasites.Open access Macedonian journal of medical sciences · 2018Article
- Polymerase chain reaction in viral anterior uveitis with secondary glaucoma: Analysis of 28 eyes from a tertiary eye care center in South India.Taiwan journal of ophthalmologyArticle
- Diagnostic microbiology for intraocular infections: A comprehensive approach.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymerase chain reaction (PCR) analysis is an important tool in the diagnosis of infectious uveitis. A retrospective, interventional study of PCR analysis of ocular fluid in suspected infectious uveitis cases between January 2014 to July 2016 was done. Nested, real-time and broad range PCR was performed for detection of the genome of Mycobacterium tuberculosis, herpes virus family, Chikungunya virus, Toxoplasma gondii, fungus, eubacterium and propionibacterium acne.
resultsTotal of 100 cases included, mean age was 39.2 ± 15.4 years. Uveitis was unilateral in 82% and granulomatous in 40%. Mean visual acuity at the initial visit and final visit was 0.73 logMar and 0.63 logMar respectively. PCR analysis confirmed the clinical diagnosis in 70.1% patients. The sensitivity, specificity, positive predictive value and negative predictive value of PCR analysis was 90.2%, 93.9%, 93.9% and 90.2% respectively. The quantitative value of real-time M. tb. Positive PCR ranged from 32c/ml to 2722 c/ml.
conclusionsPCR assay is an accurate technique with high sensitivity and specificity to diagnose the DNA genome in infectious uveitis.
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