ArticleGland surgery2017
The PGRIS and parathyroid splinting concepts for the analysis and prognosis of protracted hypoparathyroidism.
Article in Gland surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- Experience over tools: does the use of magnifying loupes reduce the incidence of transient postoperative hypocalcemia after total thyroidectomy with central neck dissection? - a single-centre prospective randomized study.Frontiers in endocrinology · 2026Trial
- Betamethasone to prevent hypocalcemia and other complications after total thyroidectomy: A retrospective case-control study.Turkish journal of surgery · 2026Article
- Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.Medicina (Kaunas, Lithuania) · 2026Article
- Reflections on prevention and treatment of post-thyroidectomy hypoparathyroidism: current management approaches and future prospects.Frontiers in endocrinology · 2026Review
- Predicting hypoparathyroidism after thyroidectomy: the value of indocyanine green fluorescence angiography.Gland surgery · 2025Article
- Article
- Optimizing Parathyroid Preservation in Thyroidectomy: The Burjeel Protocol Utilizing Intraoperative Indocyanine Green Near-Infrared Fluorescence Imaging.Biomedicines · 2025Article
- Optimal cutoff values of intraoperative parathyroid hormone for predicting early and permanent hypoparathyroidism after total thyroidectomy.Langenbeck's archives of surgery · 2025Article
- Article
- Risk factors of postoperative hypoparathyroidism after total thyroidectomy in pediatric patients with thyroid cancer.Annals of pediatric endocrinology & metabolism · 2023Article
- Parathyroid hormone of ≥1.6 pmol/L at 6 months is associated with recovery in 'long-term' post-surgical hypoparathyroidism.European thyroid journal · 2022Article
- European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.European journal of endocrinology · 2022Article
- The Reality of Hypoparathyroidism After Thyroidectomy: Which Risk Factors are Effective? Single-Center Study.Sisli Etfal Hastanesi tip bulteni · 2022Article
- MANAGEMENT OF ENDOCRINE DISEASE: Postsurgical hypoparathyroidism: current treatments and future prospects for parathyroid allotransplantation.European journal of endocrinology · 2021Review
- Etiology and Diagnosis of Permanent Hypoparathyroidism after Total Thyroidectomy.Journal of clinical medicine · 2021Review
- Is There a Regular Pattern in the Recovery of Parathyroid Function After Thyroid Cancer Surgery?Cancer management and research · 2021Article
- Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study.International journal of general medicine · 2019Article
- Complication Risk in Secondary Thyroid Surgery.Sisli Etfal Hastanesi tip bulteni · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most patients with hypocalcemia after total thyroidectomy will recover the parathyroid function in a few weeks, but some 20-30% of them will still be in the need for replacement therapy one month after surgery and about 5-10% of those will develop permanent hypoparathyroidism. Although postoperative hypocalcemia has been related to several demographic and metabolic causes, parathyroid hormone (PTH) decline, resulting from autotransplantation, inadvertent excision or devascularization of the parathyroid glands, is the common final pathway. The number of parathyroid glands remaining in situ (PGRIS) is a key variable to understand the pathogenesis of protracted hypoparathyroidism and the chances for restoration of the parathyroid function. Normal-high serum calcium concentration, probably achieved by a more intensive medical treatment at the time of hospital discharge, has been identified as an independent variable favoring recovery of the parathyroid function. This we refer to as parathyroid splinting, a hypothesis holding that putting the injured parathyroid parenchyma at rest after thyroidectomy may improve long-term outcome of protracted hypoparathyroidism.
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Registered trials
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