ArticleFEBS open bio2018
Biophysical characterization of Atg11, a scaffold protein essential for selective autophagy in yeast.
Article in FEBS open bio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Reconstitution of autophagic-like membrane tethering reveals that Atg11 can bind and cluster vesicles on cargo mimetics.Autophagy · 2026Article
- Screening Atg11, a central organizer of yeast selective autophagy, for residues involved in the Atg11-Atg9 interaction.microPublication biology · 2026Article
- Screening for residues in Atg11, a central organizer of selective autophagy in yeast, important for binding with Atg9.bioRxiv : the preprint server for biology · 2025Article
- Review
- Revisiting the evolution of the yeast Atg1 complex.Autophagy reports · 2025Article
- Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation.EMBO reports · 2024Article
- Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy.Cell reports · 2022Article
- Proteaphagy is specifically regulated and requires factors dispensable for general autophagy.The Journal of biological chemistry · 2022Article
- Mapping Critical Residues in ATG11's Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy.Frontiers in cell and developmental biology · 2021Article
- The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites.Journal of molecular biology · 2020Article
- Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation.Science (New York, N.Y.) · 2020Article
- Mechanistic Insights into the Role of Atg11 in Selective Autophagy.Journal of molecular biology · 2020Review
- Atg11 tethers Atg9 vesicles to initiate selective autophagy.PLoS biology · 2019Article
- The Multivesicular Body and Autophagosome Pathways in Plants.Frontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is an intracellular degradation system in which the formation of an autophagosome is a key event. In budding yeast, autophagosomes are generated from the preautophagosomal structure (PAS), in which Atg11 and Atg17 function as scaffolds essential for selective and nonselective types of autophagy, respectively. Structural studies have been extensively performed on Atg17, but not on Atg11, preventing us from understanding the selective type of the PAS. Here, we purified and characterized Atg11. Biophysical analyses, including analytical ultracentrifugation and CD, showed that Atg11 behaves as an elongated homodimer abundant in α-helices in solution. Moreover, truncation analyses suggested that Atg11 has a parallel coiled-coil architecture, in contrast to the antiparallel dimeric architecture of Atg17.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.