Evidence map›Paper›PMID 29321737›Full record

ArticleFrontiers in computational neuroscience2017

Propofol and Sevoflurane Differentially Modulate Cortical Depolarization following Electric Stimulation of the Ventrobasal Thalamus.

Stephan Kratzer, Corinna Mattusch, Paul S Garcia, Sebastian Schmid, Eberhard Kochs, Gerhard Rammes, Gerhard Schneider, Matthias Kreuzer, Rainer Haseneder

Open access · goldAbstract read
In one paragraph

Article in Frontiers in computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Stephan KratzerDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Corinna MattuschDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Paul S GarciaDepartment of Anesthesiology, Emory University, Atlanta, GA, United States.
Sebastian SchmidDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Eberhard KochsDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Gerhard RammesDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Gerhard SchneiderDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Matthias KreuzerDepartment of Anesthesiology, Emory University, Atlanta, GA, United States.
Rainer HasenederDepartment of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Klinikum rechts der Isar · DETechnical University of Munich · DEAtlanta VA Medical Center · US

Funding

Effects of Antiretrovirals on Neuronal Health: Screening ARVs for NeurotoxicityIK2BX001677 · VA · VETERANS HEALTH ADMINISTRATION · PI GARCIA, PAUL S · 2014 to 2018
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BLRD VA IK2 BX001677
6 · The paper itself

Abstract

The neuronal mechanisms how anesthetics lead to loss of consciousness are unclear. Thalamocortical interactions are crucially involved in conscious perception; hence the thalamocortical network might be a promising target for anesthetic modulation of neuronal information pertaining to arousal and waking behavior. General anesthetics affect the neurophysiology of the thalamus and the cortex but the exact mechanisms of how anesthetics interfere with processing thalamocortical information remain to be elucidated. Here we investigated the effect of the anesthetic agents sevoflurane and propofol on thalamocortical network activity

Indexed as

mechanisms of anesthesiapropofolsevofluranethalamocorticalunconsciousness

Identifiers

PMID29321737
PMCPMC5732174
OpenAlexW2771214028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.