ArticleScientific reports2018
Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Microbial Diversity and Composition Is Associated with Patient-Reported Toxicity during Chemoradiation Therapy for Cervical Cancer.International journal of radiation oncology, biology, physics · 2020Trial
- Nasopharyngeal Microbiome Differences Between Children with Hypertrophic Adenoids and Healthy Controls.Biology · 2026Article
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- Multi-omics profiling reveals distinct pathogenic mechanisms in Hunner and non-Hunner interstitial cystitis subtypes.Scientific reports · 2025Article
- The Lung Microbiome and Its Impact on Obstructive Sleep Apnea: A Diagnostic Frontier.Diagnostics (Basel, Switzerland) · 2025Review
- Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors.iScience · 2025Article
- Gut mucosal microbiota profiles linked to development of positional-specific human colorectal cancer.AIMS microbiology · 2024Article
- Species Delineation and Comparative Genomics within theJournal of clinical microbiology · 2023Review
- Gram-positive anaerobic cocci guard skin homeostasis by regulating host-defense mechanisms.iScience · 2023Article
- Shotgun sequencing of sonication fluid for the diagnosis of orthopaedic implant-associated infections withFrontiers in cellular and infection microbiology · 2023Article
- A Review of Recent Developments in Veterinary Otology.Veterinary sciences · 2022Review
- Association of obstructive sleep apnea severity with the composition of the upper airway microbiome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Group B Streptococcus CAMP Factor Does Not Contribute to Interactions with the Vaginal Epithelium and Is Dispensable for Vaginal Colonization in Mice.Microbiology spectrum · 2021Article
- Distinct but Intertwined Evolutionary Histories of Multiple Salmonella enterica Subspecies.mSystems · 2020Article
- Article
- The novel use of oral antibiotic monotherapy in prosthetic valve endocarditis caused by Finegoldia magna: a case study.Journal of cardiothoracic surgery · 2019Article
- The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women.Frontiers in cellular and infection microbiology · 2019Review
- Within-Species Genomic Variation and Variable Patterns of Recombination in the Tetracycline ProducerFrontiers in microbiology · 2019Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Finegoldia magna, a Gram-positive anaerobic coccus, is an opportunistic pathogen, associated with medical device-related infections. F. magna is the only described species of the genus Finegoldia. We report the analysis of 17 genomes of Finegoldia isolates. Phylogenomic analyses showed that the Finegoldia population can be divided into two distinct clades, with an average nucleotide identity of 90.7%. One clade contains strains of F. magna, whereas the other clade includes more heterogeneous strains, hereafter tentatively named "Finegoldia nericia". The latter species appears to be more abundant in the human microbiome. Surface structure differences between strains of F. magna and "F. nericia" were detected by microscopy. Strain-specific heterogeneity is high and previously identified host-interacting factors are present only in subsets of "F. nericia" and F. magna strains. However, all genomes encode multiple host factor-binding proteins such as albumin-, collagen-, and immunoglobulin-binding proteins, and two to four copies of CAMP (Christie-Atkins-Munch-Petersen) factors; in accordance, most strains show a positive CAMP reaction for co-hemolysis. Our work sheds new light of the genus Finegoldia and its ability to bind host components. Future research should explore if the genomic differences identified here affect the potential of different Finegoldia species and strains to cause opportunistic infections.
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