ArticleScientific reports2018
Chiloscyphenol A derived from Chinese liverworts exerts fungicidal action by eliciting both mitochondrial dysfunction and plasma membrane destruction.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Antifungal Activity of Surfactin AgainstBiomolecules · 2025Article
- Phytochemistry of Bryophytes: Biologically Active Compounds and Their Uses as Cosmetics, Foods, and in Drug Development.Progress in the chemistry of organic natural products · 2025Review
- N-Butylphthalide Potentiates the Effect of Fluconazole Against Drug-ResistantInfection and drug resistance · 2024Article
- Surface adherence and vacuolar internalization of bacterial pathogens to the Candida spp. cells: Mechanism of persistence and propagation.Journal of advanced research · 2023Review
- Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review.Antimicrobial agents and chemotherapy · 2023Review
- Inhibitory Effects and Mechanism of Action of Elsinochrome A onJournal of fungi (Basel, Switzerland) · 2022Article
- Emerging Antifungal Targets and Strategies.International journal of molecular sciences · 2022Review
- Review
- SWL-1 Reverses Fluconazole Resistance inFrontiers in microbiology · 2020Article
- Unusual and Highly Bioactive Sesterterpenes Synthesized byApplied and environmental microbiology · 2019Article
- Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole AgainstFrontiers in microbiology · 2019Article
- Oropharyngeal Candidosis in HIV-Infected Patients-An Update.Frontiers in microbiology · 2018Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to characterize the antifungal effects of chiloscyphenol A (CA), a natural small molecule isolated from Chinese liverworts, and investigate its mode of action. CA was effective against five tested Candida species with a minimal inhibitory concentration (MIC) of 8-32 μg/ml and exhibited fungicidal activity against Candida albicans in both the planktonic state and mature biofilms. The in vivo study using Caenorhabditis elegans showed that CA prolonged the survival of C. albicans infected worms. Further investigations revealed that CA resulted in mitochondrial dysfunction as indicated by mtΔψ hyperpolarization, increased ATP production and intracellular ROS accumulation, and aggregated distribution of Tom70. In addition, CA caused perturbation of the cell membrane and increased membrane permeability, as demonstrated by specific staining and confocal microscopic and transmission electron microscopy (TEM) observations and by calcein-leakage measurements. This conclusion was further confirmed by the decreased cell size of CA-treated cells via three-dimensional contour-plot analysis using flow cytometry. Taken together, these results suggest that CA exerts fungicidal activity by eliciting both mitochondrial dysfunction and plasma membrane destruction in C. albicans. The elucidated mechanism supports the potential application of CA against clinical fungal infections.
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