ArticleScientific reports2018
Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
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- A Vibration-Induced Emission-Based Ratiometric Sensor for Detection of Anions in Aqueous Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
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- Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation.Biochemistry and biophysics reports · 2021Article
- High-Performance Intensiometric Direct- and Inverse-Response Genetically Encoded Biosensors for Citrate.ACS central science · 2020Article
- Article
- Anion Binding Studies of Urea and Thiourea Functionalized Molecular Clefts.Frontiers in chemistry · 2020Article
- Current Advancements in Transdermal Biosensing and Targeted Drug Delivery.Sensors (Basel, Switzerland) · 2019Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to develop efficient fluorescence and color-detecting molecular probes for sensing citrate in water. Herein, we report a macrocycle-based dinuclear foldamer (1) assembled with eosin Y (EY) that has been studied for anion binding by fluorescence and colorimetric techniques in water at neutral pH. Results from the fluorescence titrations reveal that the 1·EY ensemble strongly binds citrate anions, showing remarkable selectivity over a wide range of inorganic and carboxylate anions. The addition of citrate anions to the 1·EY adduct led to a large fluorescence enhancement, displaying a detectable color change under both visible and UV light in water up to 2 μmol. The biocompatibility of 1·EY as an intracellular carrier in a biological system was evaluated on primary human foreskin fibroblast (HF) cells, showing an excellent cell viability. The strong binding properties of the ensemble allow it to be used as a highly sensitive, detective probe for biologically relevant citrate anions in various applications.
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