ArticleInternal medicine (Tokyo, Japan)2018
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Efficacy of Rituximab on Refractory Organ Involvements in Granulomatosis with Polyangiitis: A Systematic Review of Case Reports.Current rheumatology reviews · 2024Pooled it
- Necrotizing Scleritis in Granulomatosis With Polyangiitis: A Clinical Challenge for an Ophthalmologists.Case reports in ophthalmological medicine · 2026Article
- Isolated ANCA-associated scleritis successfully treated with systemic rituximab; a case report and review of literature.BMC ophthalmology · 2025Review
- Recurrent strokes as the sole manifestation of antineutrophil cytoplasmic antibody associated vasculitis in a patientwith panuveitis: a case report.Journal of ophthalmic inflammation and infection · 2025Article
- The primary systemic vasculitis associated optic neuritis: a retrospective analysis in a single center over 10 years.International ophthalmology · 2024Article
- ANCA-associated vasculitis presenting with progressive binocular manifestations: a case report and literature review.Frontiers in medicine · 2024Article
- ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review.Clinical case reports · 2023Article
- A Case of an Elderly Woman Who Developed Corneal Perforation in the Clinical Course of Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.Case reports in rheumatology · 2023Article
- Baricitinib in severe and refractory peripheral ulcerative keratitis: a case report and literature review.Therapeutic advances in musculoskeletal disease · 2022Article
- Biologic Therapies and Small Molecules for the Management of Non-Infectious Scleritis: A Narrative Review.Ophthalmology and therapy · 2021Review
- Rituximab for non-infectious Uveitis and Scleritis.Journal of ophthalmic inflammation and infection · 2021Review
- Commentary: Rituximab in scleritis.Indian journal of ophthalmology · 2020Article
- Therapy of ocular complications in ANCA+ associated vasculitis.Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
20 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 67-year-old Japanese man was diagnosed with granulomatosis with polyangiitis based on the presence of right maxillary sinusitis, proteinase 3 antineutrophil cytoplasmic antibody positivity, and right scleritis. A conjunctival biopsy specimen showed neutrophil-predominant infiltration around the vessels without granuloma. Because there was a risk of blindness, pulsed methylprednisolone and intravenous cyclophosphamide pulse therapy (IVCY) were started. However, it was ineffective, and peripheral ulcerative keratitis newly emerged. We promptly switched the treatment from IVCY to rituximab, and ophthalmologists performed amniotic membrane transplantation, which avoided blindness. The close and effective working relationship between physicians and ophthalmologists improved our patient's ocular prognosis.
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Registered trials
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