ArticleStroke2018
Neuroimaging Identifies Patients Most Likely to Respond to a Restorative Stroke Therapy.
Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Measured and Perceived Effects of Upper Limb Home-Based Exergaming Interventions on Activity after Stroke: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Test-retest reliability and minimal detectable change of corticospinal tract integrity in chronic stroke.Human brain mapping · 2020Trial
- Characterizing ipsilateral thalamic diaschisis in symptomatic cerebrovascular steno-occlusive patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Variability in stroke motor outcome is explained by structural and functional integrity of the motor system.Scientific reports · 2018Trial
- Review
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Corticomuscular Coherence in Post-Stroke Motor Function and Recovery.Brain sciences · 2026Article
- Optimizing the Approach to Calculating CST Lesion Load in Ischemic Stroke Patients for Understanding Motor Outcomes.Neurorehabilitation and neural repair · 2026Article
- Towards AI-based precision rehabilitation via contextual model-based reinforcement learning.Journal of neuroengineering and rehabilitation · 2025Article
- Article
- Post-stroke spontaneous motor recovery in mice can be predicted from acute-phase local field potential using machine learning.APL bioengineering · 2025Article
- Changing genes, cells and networks to reprogram the brain after stroke.Nature neuroscience · 2025Review
- Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.Neurology · 2025Article
- Disconnection syndromes and injury to neural systems after ischemic stroke.Frontiers in stroke · 2025Article
- Associations between structural injury and task-based corticomuscular connectivity after stroke.Frontiers in neurology · 2025Article
- Microstructure of the residual corticofugal projection from primary motor cortex in chronic stroke.Brain communications · 2025Article
- Corticospinal Tract Sparing in Cervical Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery.Neurorehabilitation and neural repair · 2024Article
- Responsiveness to exoskeleton loading during bimanual reaching is associated with corticospinal tract integrity in stroke.Frontiers in neuroscience · 2024Article
- Predicting Motor Outcomes Using Atlas-Based Voxel Features of Post-Stroke Neuroimaging: A Scoping Review.Neurorehabilitation and neural repair · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposePatient heterogeneity reduces statistical power in clinical trials of restorative therapies. Valid predictors of treatment responsiveness are needed, and several have been studied with a focus on corticospinal tract (CST) injury. We studied performance of 4 such measures for predicting behavioral gains in response to motor training therapy.
methodsPatients with subacute-chronic hemiparetic stroke (n=47) received standardized arm motor therapy, and change in arm Fugl-Meyer score was calculated from baseline to 1 month post-therapy. Injury measures calculated from baseline magnetic resonance imaging included (1) percent CST overlap with stroke, (2) CST-related atrophy (cerebral peduncle area), (3) CST integrity (fractional anisotropy) in the cerebral peduncle, and (4) CST integrity in the posterior limb of internal capsule.
resultsPercent CST overlap with stroke, CST-related atrophy, and CST integrity did not correlate with one another, indicating that these 3 measures captured independent features of CST injury. Percent injury to CST significantly predicted treatment-related behavioral gains (
conclusionsPercent CST injury is useful for predicting motor gains in response to therapy in the setting of subacute-chronic stroke. This measure can be used as an entry criterion or a stratifying variable in restorative stroke trials to increase statistical power, reduce sample size, and reduce the cost of such trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.