Evidence map›Paper›PMID 29321323›Full record

ArticleJournal of virology2018

HIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific.

Edward L Evans, Jordan T Becker, Stephanie L Fricke, Kishan Patel, Nathan M Sherer

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Manipulation of the cell cycle by HIV-1.Biochemical Society transactions · 2026
    Review
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  5. HIV-1 Vif and Vpr cooperatively modulate the cell cycle to maximize per-cell virion production.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Edward L EvansMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jordan T BeckerMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-0239-5443
Stephanie L FrickeMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kishan PatelMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nathan M ShererMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin, USA nsherer@wisc.edu.
University of Wisconsin–Madison · US

Funding

Training in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4M
The Cell Biology of HIV-1 Genome TraffickingR01AI110221 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Nathan M Sherer · 2014 to 2026
$4.4M
NCI NIH HHS T32 CA009135NIAID NIH HHS R01 AI110221
6 · The paper itself

Abstract

Cells derived from mice and other rodents exhibit profound blocks to HIV-1 virion production, reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential host factors cyclin T1 (CCNT1) and exportin-1 (XPO1, also known as CRM1), respectively. To determine if mouse cell blocks other than CCNT1 and XPO1 affect HIV's postintegration stages, we studied HIV-1

Indexed as

G2 Phase Cell Cycle CheckpointsM Phase Cell Cycle CheckpointsAnimalsAPOBEC-3G DeaminaseChlorocebus aethiopsCHO CellsCOS CellsCricetulusCyclin TExportin 1 ProteinHeLa CellsHIV-1HumansKaryopherinsMiceNIH 3T3 CellsAPOBEC-3G DeaminaseAPOBEC3G protein, humanAPOBEC3G protein, mouseCCNT1 protein, humanCcnt1 protein, mouseCyclin TExportin 1 ProteinKaryopherinsReceptors, Cytoplasmic and Nuclearvif Gene Products, Human Immunodeficiency Virusvif protein, Human immunodeficiency virus 1APOBEC3Gcell cyclecyclin T1exportin-1G2/MHIVPPP2R5DRevspecies specificVif

Identifiers

PMID29321323
PMCPMC5972884
OpenAlexW2782558321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.