Evidence map›Paper›PMID 29321302›Full record

ArticleProceedings. Biological sciences2018

Rapid seasonal evolution in innate immunity of wild

Emily L Behrman, Virginia M Howick, Martin Kapun, Fabian Staubach, Alan O Bergland, Dmitri A Petrov, Brian P Lazzaro, Paul S Schmidt

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  10. Evolution letters · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Emily L BehrmanDepartment of Biology, University of Pennsylvania, 433 S. University Ave., Philadelphia, PA 19104, USA bemily@sas.upenn.edu.ORCID 0000-0002-2472-9635
Virginia M HowickDepartment of Entomology, Cornell University, 3125 Comstock Hall, Ithaca, NY 14853, USA.ORCID 0000-0003-3054-2460
Martin KapunDepartment of Ecology and Evolution, University of Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0002-3810-0504
Fabian StaubachDepartment of Biology, Stanford University, 371 Serra St, Stanford, CA 94305-5020, USA.ORCID 0000-0002-8097-2349
Alan O BerglandDepartment of Biology, Stanford University, 371 Serra St, Stanford, CA 94305-5020, USA.ORCID 0000-0001-7145-7575
Dmitri A PetrovDepartment of Biology, Stanford University, 371 Serra St, Stanford, CA 94305-5020, USA.ORCID 0000-0002-3664-9130
Brian P LazzaroDepartment of Entomology, Cornell University, 3125 Comstock Hall, Ithaca, NY 14853, USA.ORCID 0000-0002-3881-0995
Paul S SchmidtDepartment of Biology, University of Pennsylvania, 433 S. University Ave., Philadelphia, PA 19104, USA.ORCID 0000-0002-8076-6705
Cornell University · USUniversity of Pennsylvania · USStanford University · USUniversity of Freiburg · DEUniversity of Lausanne · CHUniversity of Virginia · US

Funding

Genomics of rapid adaptation in the lab and in the wildR35GM118165 · NIGMS · STANFORD UNIVERSITY · PI Dmitri Petrov · 2016 to 2026
$8.3M
Genomics of rapid adaptation on seasonal timescales in D. melanogasterR01GM100366 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SCHMIDT, PAUL · 2012 to 2019
$3.3M
Genetic Network Linking Immunity to Energetic Stress, Metabolism and ReproductionR01AI083932 · NIAID · CORNELL UNIVERSITY · PI LAZZARO, BRIAN · 2009 to 2015
$2.6M
NIAID NIH HHS R01 AI083932NIGMS NIH HHS R01 GM100366NIGMS NIH HHS R35 GM118165
6 · The paper itself

Abstract

Understanding the rate of evolutionary change and the genetic architecture that facilitates rapid adaptation is a current challenge in evolutionary biology. Comparative studies show that genes with immune function are among the most rapidly evolving genes across a range of taxa. Here, we use immune defence in natural populations of

Indexed as

Evolution, MolecularSeasonsAdaptation, PhysiologicalAnimalsDrosophila melanogasterDrosophila ProteinsEnterococcus faecalisFemaleImmunity, InnateMaleMassachusettsPennsylvaniaProvidenciaVirginiaDrosophila ProteinsDrosomycin-like 6Drosophila melanogasterepistasisinnate immunityrapid adaptationThioester-containing protein 3

Identifiers

PMID29321302
PMCPMC5784205
OpenAlexW2752203640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.