Evidence map›Paper›PMID 29321261›Full record

ArticleThe Journal of general physiology2018

A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers.

Rahul Chadda, Lucy Cliff, Marley Brimberry, Janice L Robertson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Dimerization mechanism of an inverted-topology ion channel in membranes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Membrane defects as a generalized driving force for membrane protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. A thermodynamic analysis of CLC transporter dimerization in lipid bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Review
  10. Membrane proteins enter the fold.Current opinion in structural biology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. The lipid bilayer membrane and its protein constituents.The Journal of general physiology · 2018
    Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Rahul ChaddaDepartment of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA.ORCID 0000-0001-6710-3985
Lucy CliffDepartment of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA.ORCID 0000-0001-5113-6635
Marley BrimberryDepartment of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA.
Janice L RobertsonDepartment of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA janice-robertson@uiowa.edu.ORCID 0000-0002-5499-9943
University of Iowa · US

Funding

Driving forces of membrane protein assembly in membranesR01GM120260 · NIGMS · WASHINGTON UNIVERSITY · PI ROBERTSON, JANICE L · 2016 to 2024
$3.4M
Reversible dimerization of a CLC transporter: A model for membrane protein foldinR00GM101016 · NIGMS · UNIVERSITY OF IOWA · PI ROBERTSON, JANICE L · 2013 to 2015
$727k
Debugging eukaryotic membrane protein expression in E. coli using single-molecule fluorescence microscopyR21GM126476 · NIGMS · WASHINGTON UNIVERSITY · PI ROBERTSON, JANICE L · 2018 to 2019
$427k
NIGMS NIH HHS R00 GM101016NIGMS NIH HHS R01 GM120260NIGMS NIH HHS R21 GM126476
6 · The paper itself

Abstract

The thermodynamic reasons why membrane proteins form stable complexes inside the hydrophobic lipid bilayer remain poorly understood. This is largely because of a lack of membrane-protein systems amenable for equilibrium studies and a limited number of methods for measuring these reactions. Recently, we reported the equilibrium dimerization of the CLC-ec1 Cl

Indexed as

Protein MultimerizationAnimalsAntiportersEscherichia coli ProteinsHumansLipid BilayersThermodynamicsAntiportersCLC-ec1 protein, E coliEscherichia coli ProteinsLipid Bilayers

Identifiers

PMID29321261
PMCPMC5806674
OpenAlexW2950089318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.