Evidence map›Paper›PMID 29321243›Full record

ArticleThe Biochemical journal2018

Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes.

Connie Hung, Casey Bronec, Eleonora Napoli, James Graham, Kimber L Stanhope, Ilaria Marsilio, Maria Cecilia Giron, Peter J Havel, Cecilia Giulivi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The Effects of MixedToxins · 2021
    Article
  3. Ileal interposition surgery targets the hepatic TGF-β pathway, influencing gluconeogenesis and mitochondrial bioenergetics in the UCD-T2DM rat model of diabetes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Connie HungDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
Casey BronecDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
Eleonora NapoliDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
James GrahamDepartment of Nutrition, University of California, Davis, CA 95616, U.S.A.
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
Ilaria MarsilioDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
Maria Cecilia GironDepartment of Pharmaceutical and Pharmacological Sciences, Pharmacology Building, University of Padova, Largo Meneghetti 2, 35131 Padova, Italy.
Peter J HavelDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
Cecilia GiuliviDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A. cgiulivi@ucdavis.edu.ORCID 0000-0003-1033-7435

Funding

Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondriaRC1DK087307 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GIULIVI, CECILIA, HAVEL, PETER J · 2009 to 2010
$985k
NIDDK NIH HHS RC1 DK087307
6 · The paper itself

Abstract

Ileal interposition (IT) surgery delays the onset of diabetes in a rat model of type-2 diabetes (UCD-T2DM). Here, to gain a deeper understanding of the molecular events underlying the effects of IT surgery, we examined the changes in the proteome of four white adipose depots (retroperitoneal, mesenteric, inguinal, and epididymal) and plasma-free fatty acid profile in pre-diabetic rats 1.5 months following IT or sham surgery. The IT-mediated changes were exerted mainly in mesenteric fat and spanned from delayed adipocyte maturation to a neuroendocrine remodeling. Conversely, inguinal, retroperitoneal, and epididymal depots showed opposite trends consistent with increased adipocyte maturation and adipogenesis development prior to overt signs of diabetes, probably orchestrated by peroxisome proliferator-activated receptor gamma signaling and higher plasma

Indexed as

AdipocytesAdipogenesisAdipose TissueAdipose Tissue, WhiteAnimalsDiabetes Mellitus, Type 2Disease Models, AnimalFatty Acids, Omega-3Fatty Acids, Omega-6HumansIleumLipid MetabolismObesityProteomeRatsFatty Acids, Omega-3Fatty Acids, Omega-6Proteomelipidomicsobesityproteomicsrat modelstype 2 diabeteswhite adipose tissue

Identifiers

PMID29321243
PMCPMC7061453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.