Evidence map›Paper›PMID 29321206›Full record

ArticleThe Journal of biological chemistry2018

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first).

Zhen Han, Hong Wu, Sunjoo Kim, Xiangkun Yang, Qianjin Li, He Huang, Houjian Cai, Michael G Bartlett, Aiping Dong, Hong Zeng and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer.Frontiers in cell and developmental biology · 2021
    Pooled it
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  20. MOF moves into mitochondria.Nature metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Zhen HanFrom the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602.
Hong Wuthe Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Sunjoo Kimthe Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637.
Xiangkun YangFrom the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602.
Qianjin LiFrom the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602.
He Huangthe Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637.
Houjian CaiFrom the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602.
Michael G BartlettFrom the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602.
Aiping Dongthe Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Hong Zengthe Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Peter J Brownthe Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Xiang-Jiao Yangthe Goodman Cancer Research Center and Department of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada, and.
Cheryl H Arrowsmiththe Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Yingming Zhaothe Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637.
Y George ZhengFrom the Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, yzheng@uga.edu.
University of Georgia · USUniversity of Chicago · USStructural Genomics Consortium · CAUniversity of Toronto · CAMcGill University · CAPrincess Margaret Cancer Centre · CA

Funding

Systems-wide analysis of histone lysine 2-hydroxyisobutyrylation pathwayR01GM115961 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHAO, YINGMING · 2016 to 2019
$1.8M
Targeting myristoylation of Src family kinases for inhibition of prostate tumorigenesisR01CA172495 · NCI · UNIVERSITY OF GEORGIA · PI CAI, HOUJIAN · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA172495NIGMS NIH HHS R01 GM115961Wellcome Trust
6 · The paper itself

Abstract

Short-chain acylation of lysine residues has recently emerged as a group of reversible posttranslational modifications in mammalian cells. The diversity of acylation further broadens the landscape and complexity of the proteome. Identification of regulatory enzymes and effector proteins for lysine acylation is critical to understand functions of these novel modifications at the molecular level. Here, we report that the MYST family of lysine acetyltransferases (KATs) possesses strong propionyltransferase activity both

Indexed as

Protein Processing, Post-TranslationalAcetylationAmino Acid SequenceHEK293 CellsHistone AcetyltransferasesHumansLysineModels, MolecularProtein ConformationProteomicsHistone AcetyltransferasesKAT8 protein, humanLysineacetyltransferasecrystal structurelysine propionylationMales absent on the first (MOF)post-translational modification (PTM)protein acylationproteomics

Identifiers

PMID29321206
PMCPMC5836141
OpenAlexW2783301628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.