Evidence map›Paper›PMID 29321181›Full record

ReviewDevelopment (Cambridge, England)2018

Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond.

Emery H Bresnick, Kyle J Hewitt, Charu Mehta, Sunduz Keles, Robert F Paulson, Kirby D Johnson

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Erythroid Cell Research: 3D Chromatin, Transcription Factors and Beyond.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
  15. Proteomic/transcriptomic analysis of erythropoiesis.Current opinion in hematology · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emery H BresnickDepartment of Cell and Regenerative Biology, UW-Madison Blood Research Program, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA ehbresni@wisc.edu.ORCID 0000-0002-1151-5654
Kyle J HewittDepartment of Cell and Regenerative Biology, UW-Madison Blood Research Program, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Charu MehtaDepartment of Cell and Regenerative Biology, UW-Madison Blood Research Program, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Sunduz KelesDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Robert F PaulsonDepartment of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.
Kirby D JohnsonDepartment of Cell and Regenerative Biology, UW-Madison Blood Research Program, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Hematopoietic Regulation via GATA SwitchesR01DK068634 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Emery H. Bresnick · 2006 to 2026
$7.5M
Transcriptional Control of Hemoglobin Synthesis and Erythrocyte DevelopmentR01DK050107 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Emery H. Bresnick · 1996 to 2026
$6.1M
Transcriptional Control of Hemoglobin SynthesisR37DK050107 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BRESNICK, EMERY H · 2011 to 2020
$3.5M
The BMP4 dependent stress erythropoiesis pathway in short-term radioprotectionR01DK080040 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAULSON, ROBERT FRANK · 2009 to 2017
$2.6M
Balancing Erythroid Progenitor Self-Renewal and DifferentiationR01DK113186 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BRESNICK, EMERY H · 2018 to 2020
$809k
Mechanisms of a GATA Factor-Dependent Hematopoietic Signaling PathwayK01DK113117 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HEWITT, KYLE J · 2017 to 2018
$199k
NCI NIH HHS P30 CA014520NHLBI NIH HHS T32 HL007936NIDDK NIH HHS K01 DK113117NIDDK NIH HHS R01 DK050107NIDDK NIH HHS R01 DK068634NIDDK NIH HHS R01 DK080040NIDDK NIH HHS R01 DK113186NIDDK NIH HHS R37 DK050107
6 · The paper itself

Abstract

Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed 'stress erythropoiesis' to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

Indexed as

AnimalsBiological Transport, ActiveCell DifferentiationErythrocytesErythropoiesisHematopoietic Stem CellsHumansOxygenRegenerationOxygenErythroblastErythrocyteRegenerationStressTranscription

Identifiers

PMID29321181
PMCPMC5825862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.