Trial reportBlood2018
Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency.
Trial report in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 2/3, Open-Label, Repeat-Dose Study of the Pharmacokinetics, Efficacy, and Safety of Prometic Plasminogen Intravenous Infusion in Subjects With Hypoplasminogenemia
Hypoplasminogenemia: An International RetroSpecTive and PrOspective CohoRt StudY (HISTORY)
The Use of Allogenic Plasma Aliquots as a Source of Plasminogen in the Treatment of Ligneous Conjunctivitis, Clinical Trial of One Case
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study.Intensive care medicine · 2026Trial
- Safety and Efficacy of Long-Term Treatment of Type 1 Plasminogen Deficient Patients With Intravenous Plasminogen Replacement Therapy.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Trial
- Plasminogen Activation System and Fibroblasts: Impact on Tissue Remodeling, Disease, and Organ Homeostasis.Inflammation · 2026Review
- Pleural Space Diseases and Their Management: What is the Role of Intrapleural Fibrinolytic Therapy?The American surgeon · 2025Review
- Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease.Scientific reports · 2024Article
- New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia.Communications biology · 2024Article
- Case Report: Respiratory lesions successfully treated with intravenous plasminogen, human-tvmh, replacement therapy in four patients with plasminogen deficiency type 1.Frontiers in pediatrics · 2024Article
- Ligneous conjunctivitis: Fresh-frozen plasma and heparin use intra-and postoperatively, a report of two cases.Arquivos brasileiros de oftalmologia · 2024Article
- Article
- Plasminogen Deficiency: A Case Report and Review.Cureus · 2023Article
- Combined medical and surgical approach in the management of ligneous conjunctivitis in a pediatric patient: A case report.International journal of surgery case reports · 2023Article
- Long-term follow-up in a pediatric patient with Ligneous Conjunctivitis due to PLG gene mutation in topical plasminogen treatment after successful use of ocular prosthesis for aesthetic rehabilitation: a case report.Italian journal of pediatrics · 2023Article
- Review
- Recurrent ligneous conjunctivitis after cataract surgery in a 67-year-old male patient: a case report.BMC ophthalmology · 2022Article
- The Pharmaceutical Year that was, 2021.Pharmaceutical medicine · 2021Article
- Plasminogen Receptors and Fibrinolysis.International journal of molecular sciences · 2021Review
- Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- The plasminogen receptor, Plg-RCell death & disease · 2020Article
- An international registry of patients with plasminogen deficiency (HISTORY).Haematologica · 2020Review
- Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature.Case reports in dentistry · 2020Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital plasminogen deficiency is caused by mutations in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.