Trial reportCirculation. Cardiovascular quality and outcomes2018
Efficacy of a Chronic Care-Based Intervention on Secondary Stroke Prevention Among Vulnerable Stroke Survivors: A Randomized Controlled Trial.
Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Circulation. Cardiovascular quality and outcomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00861081 (RCT of an Intervention to Enable Stroke Survivors in Los Angeles County Hospitals to "Stay Within the Guidelines"), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
RCT of an Intervention to Enable Stroke Survivors in Los Angeles County Hospitals to "Stay Within the Guidelines" (SUSTAIN)
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Theory-Based Self-Management Interventions for Community-Dwelling Stroke Survivors: A Systematic Review and Meta-Analysis.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2022Pooled it
- Effectiveness of physical activity interventions delivered or prompted by health professionals in primary care settings: systematic review and meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2022Pooled it
- Effect and efficacy of lifestyle interventions as secondary prevention.Acta neurologica Scandinavica · 2020Pooled it
- General lifestyle interventions on their own seem insufficient to improve the level of physical activity after stroke or TIA: a systematic review.BMC neurology · 2020Pooled it
- Framingham Risk Score Prediction at 12 Months in the STANDFIRM Randomized Control Trial.Journal of the American Heart Association · 2025Trial
- Effect of a Coordinated Community and Chronic Care Model Team Intervention vs Usual Care on Systolic Blood Pressure in Patients With Stroke or Transient Ischemic Attack: The SUCCEED Randomized Clinical Trial.JAMA network open · 2021Trial
- Trial
- Applications of ICF-Based Assessments and Interventions in Post-Stroke Rehabilitation: A Narrative Review.NeuroRehabilitation · 2026Review
- Ethnic disparities in the longer-term clinical care and outcomes of stroke patients in England.PloS one · 2026Observational
- Multilevel Interventions Demonstrate Mixed Effectiveness for Improving Blood Pressure Outcomes: A Rapid Review.Healthcare (Basel, Switzerland) · 2025Review
- Post 90-day outcomes of acute ischemic stroke patients following thrombectomy: analysis of real-world data.Frontiers in neurology · 2025Article
- Enhancing patient-reported outcomes in stroke care: a path to improved well-being.Frontiers in neurology · 2025Article
- Lobar intracerebral hemorrhage and risk of subsequent uncontrolled blood pressure.European stroke journal · 2022Article
- Secondary Stroke Prevention in Polish Adults: Results from the LIPIDOGRAM2015 Study.Journal of clinical medicine · 2021Article
- Stroke Disparities: From Observations to Actions: Inaugural Edward J. Kenton Lecture 2020.Stroke · 2020Article
- Review
- Review
- A randomized controlled trial of brain and heart health manager-led mHealth secondary stroke prevention.Cardiovascular diagnosis and therapy · 2020Article
- Derivation and Application of a Tool to Estimate Benefits From Multiple Therapies That Reduce Recurrent Stroke Risk.Stroke · 2020Article
- A high-risk population for stroke recurrence exists among home-based stroke survivors discharged from an acute care hospital: A retrospective analysis.JRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Eric M ChengFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.). echeng@mednet.ucla.edu.
William E CunninghamFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Amytis TowfighiFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Nerses SanossianFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Robert J BrygFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Thomas L AndersonFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Frances BarryFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Susan M DouglasFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Lillie HudsonFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Monica Ayala-RiveraFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Jeffrey J GutermanFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Sandra Gross-SchulmanFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Sylvia BeanesFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Andrea S JonesFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Honghu LiuFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
Barbara G VickreyFrom the Department of Neurology (E.M.C., F.B., S.M.D., L.H., M.A.-R., B.G.V.) and Department of Medicine (W.E.C., H.L.), UCLA David Geffen School of Medicine; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA (A.T.); Department of Neurology, Keck School of Medicine of USC, Los Angeles (N.S.); Department of Medicine, Olive View-UCLA Medical Center, Sylmar (R.J.B.); Department of Medicine, Harbor-UCLA Medical Center, Torrance (T.L.A.); Los Angeles County Department of Health Services, Sylmar, CA (J.J.G., S.G.-S.); American Heart Association, Los Angeles, CA (S.B.); Healthy African American Families Phase II, Los Angeles, CA (A.S.J.); UCLA School of Dentistry (H.L.); and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).
American Heart Association · USHarbor–UCLA Medical Center · USUCLA Medical Center · USKeck Hospital of USC · USLos Angeles County Department of Health Services · USRancho Los Amigos National Rehabilitation Center · USHealthy African American Families II · US
Funding
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5MThe Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE A SARKISIAN · 2002 to 2026
$19.7MTRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI MILBURN, NORWEETA GERMAINE, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5MSecondary Stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities: the SUCCEED TrialU54NS081764 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BROWN, ARLEEN F. · 2012 to 2016
$11.3MDREW/UCLA Project Export CenterP20MD000148 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHAPIRO, MARTIN F · 2002 to 2006
$3.6MNIA NIH HHS P30 AG021684NIMHD NIH HHS P20 MD000148NIMHD NIH HHS P20 MD000182NIMH NIH HHS P30 MH058107NINDS NIH HHS U54 NS081764
Abstract
backgroundDisparities of care among stroke survivors are well documented. Effective interventions to improve recurrent stroke preventative care in vulnerable populations are lacking. METHODS AND
resultsIn a randomized controlled trial, we tested the efficacy of components of a chronic care model-based intervention versus usual care among 404 subjects having an ischemic stroke or transient ischemic attack within 90 days of enrollment and receiving care within the Los Angeles public healthcare system. Subjects had baseline systolic blood pressure (SBP) ≥120 mm Hg. The intervention included a nurse practitioner/physician assistant care manager, group clinics, self-management support, report cards, decision support, and ongoing care coordination. Outcomes were collected at 3, 8, and 12 months, analyzed as intention-to-treat, and used repeated-measures mixed-effects models. Change in SBP was the primary outcome. Low-density lipoprotein reduction, antithrombotic medication use, smoking cessation, and physical activity were secondary outcomes. Average age was 57 years; 18% were of black race; 69% were of Hispanic ethnicity. Mean baseline SBP was 150 mm Hg in both arms. SBP decreased to 17 mm Hg in the intervention arm and 14 mm Hg in the usual care arm; the between-arm difference was not significant (-3.6 mm Hg; 95% confidence interval, -9.2 to 2.2). Among secondary outcomes, the only significant difference was that persons in the intervention arm were more likely to lower their low-density lipoprotein <100 md/dL (2.0 odds ratio; 95% confidence interval, 1.1-3.5).
conclusionsThis intervention did not improve SBP control beyond that attained in usual care among vulnerable stroke survivors. A community-centered component could strengthen the intervention impact. CLINICAL
trial registrationURL: https://clinicaltrials.gov. Unique identifier: NCT00861081.
Indexed as
SurvivorsVulnerable PopulationsAgedBlack or African AmericanChronic DiseaseCommunity Health ServicesDelivery of Health Care, IntegratedFemaleHealthcare DisparitiesHealth StatusHealth Status DisparitiesHispanic or LatinoHumansIschemic Attack, TransientLong-Term CareLos Angelesblood pressureexerciserisk factorssecondary preventionstroke
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Registered trials
NCT00861081ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.