ArticleCell reports2018
Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Integrated drivers of basal and acute immunity in diverse human populations.Cell reports. Medicine · 2026Article
- Analysis of respiratory pathogen detection in hospitalized children with acute respiratory tract infections after ending the zero COVID policy.Scientific reports · 2024Article
- SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections.Nature communications · 2024Article
- Genome-Wide Interaction Study of Late-Onset Asthma With Seven Environmental Factors Using a Structured Linear Mixed Model in Europeans.Frontiers in genetics · 2022Article
- Identifying Methylation Signatures and Rules for COVID-19 With Machine Learning Methods.Frontiers in molecular biosciences · 2022Article
- Age-Related Increase of Collagen/Fibrin Deposition and High PAI-1 Production in Human Nasal Polyps.Frontiers in pharmacology · 2022Article
- Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.The Lancet. Microbe · 2021Article
- Mycoplasma pneumoniae P1 Genotype Indicates Severity of Lower Respiratory Tract Infections in Children.Journal of clinical microbiology · 2021Article
- A comparison of host response strategies to distinguish bacterial and viral infection.PloS one · 2021Article
- Age-Dependent Differences in T-Cell Responses to Influenza A Virus.American journal of respiratory cell and molecular biology · 2020Review
- Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Acute respiratory tract viral infections (ARTIs) cause significant morbidity and mortality. CD8 T cells are fundamental to host responses, but transcriptional alterations underlying anti-viral mechanisms and links to clinical characteristics remain unclear. CD8 T cell transcriptional circuitry in acutely ill pediatric patients with influenza-like illness was distinct for different viral pathogens. Although changes included expected upregulation of interferon-stimulated genes (ISGs), transcriptional downregulation was prominent upon exposure to innate immune signals in early IFV infection. Network analysis linked changes to severity of infection, asthma, sex, and age. An influenza pediatric signature (IPS) distinguished acute influenza from other ARTIs and outperformed other influenza prediction gene lists. The IPS allowed a deeper investigation of the connection between transcriptional alterations and clinical characteristics of acute illness, including age-based differences in circuits connecting the STAT1/2 pathway to ISGs. A CD8 T cell-focused systems immunology approach in pediatrics identified age-based alterations in ARTI host response pathways.
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Registered trials
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