Evidence map›Paper›PMID 29320709›Full record

ArticleCell metabolism2018

Metabolic Reprogramming via Targeting CD38 NADase Augments Adoptive T Cell Therapy.

Mario R Fernandez, John L Cleveland

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. NADCell & bioscience · 2023
    Review
  3. Research progress in the role of CD38 in clinical tumor treatment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Mario R FernandezDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
John L ClevelandDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address: john.cleveland@moffitt.org.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
"Research Supplement to Promote Diversity in Health-Related Research", as part of Moffitt PS-OC, "Cancer as a Complex adaptive System"U54CA193489 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ANDERSON, ALEXANDER ROBERTSON ALLAN, GATENBY, ROBERT A · 2015 to 2020
$12.5M
Sequence-based Design of Small Molecules Targeting RNAR01GM097455 · NIGMS · SCRIPPS FLORIDA · PI DISNEY, MATTHEW D · 2012 to 2019
$4.6M
High Throughput Screening to Discover Ulk1 Kinase InhibitorsR01GM113972 · NIGMS · SCRIPPS FLORIDA · PI CLEVELAND, JOHN L., DUCKETT, DEREK RONALD · 2015 to 2017
$1.5M
Role of branched-chain amino catabolism in lymphopoiesis and lymphomagenesisF32CA203217 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI FERNANDEZ, MARIO R · 2016 to 2018
$184k
NCI NIH HHS F32 CA203217NCI NIH HHS P30 CA076292NCI NIH HHS U54 CA193489NIGMS NIH HHS R01 GM097455NIGMS NIH HHS R01 GM113972
6 · The paper itself

Abstract

One strategy to improve the potency of adoptive T cell therapy is to augment the function and persistence of anti-tumor T cells. In this issue of Cell Metabolism, Chatterjee et al. (2018) demonstrate that intratumoral CD4

Indexed as

NAD+ NucleosidaseNeoplasmsADP-ribosyl Cyclase 1Cell- and Tissue-Based TherapyHumansNADADP-ribosyl Cyclase 1NADNAD+ Nucleosidase

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.