ArticleBiophysical journal2018
Effects of pH and Salt Concentration on Stability of a Protein G Variant Using Coarse-Grained Models.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- pH-Dependent Stability and Cooperativity of Protein Unfolding from Differential Scanning Calorimetry Using FitFoldData.Biomolecules · 2026Article
- The Effects of pH on Orientations of Adsorbed Lysozyme on Negatively Charged Surfaces.The journal of physical chemistry. B · 2026Article
- Probing Charge-Controlled Inter-Domain Flexibility: Integrating Experimental and Coarse-Grained Approaches.Journal of chemical information and modeling · 2026Article
- Subcellular localization as a driver of protein function.Nature reviews. Molecular cell biology · 2026Review
- Insight into Malt1 activation mechanism through synergetic approach of AlphaFold, MD Simulation and NMR dynamic analyses.bioRxiv : the preprint server for biology · 2025Article
- Optimization of forward extraction and functional properties of soy 11S globulin by reverse micelles with chaotropic agents.Food science and biotechnology · 2025Article
- Mapping the energy landscape of a fold-switching protein MAD2.Protein science : a publication of the Protein Society · 2025Article
- From efficiency to sustainability: organic additives for interfacial regulation in lithium metal batteries.Chemical science · 2025Review
- Article
- Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.Analytical chemistry · 2023Article
- FireProt 2.0: web-based platform for the fully automated design of thermostable proteins.Briefings in bioinformatics · 2023Article
- Energy Transport alongMaterials (Basel, Switzerland) · 2022Article
- Targeted protein degradation: A promise for undruggable proteins.Cell chemical biology · 2021Review
- Article
- Electrostatic interaction optimization improves catalytic rates and thermotolerance on xylanases.Biophysical journal · 2021Article
- The high stability of the three-helix bundle UBA domain of p62 protein as revealed by molecular dynamics simulations.Journal of molecular modeling · 2021Article
- Storage stability of soy protein isolate powders containing soluble protein aggregates formed at varying pH.Food science & nutrition · 2020Article
- Interdomain Flexibility within NADPH Oxidase Suggested by SANS Using LMNG Stealth Carrier.Biophysical journal · 2020Article
- The Role of Electrostatics and Folding Kinetics on the Thermostability of Homologous Cold Shock Proteins.Journal of chemical information and modeling · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of charge-charge interactions in the thermal stability of proteins is widely known. pH and ionic strength play a crucial role in these electrostatic interactions, as well as in the arrangement of ionizable residues in each protein-folding stage. In this study, two coarse-grained models were used to evaluate the effect of pH and salt concentration on the thermal stability of a protein G variant (1PGB-QDD), which was chosen due to the quantity of experimental data exploring these effects on its stability. One of these coarse-grained models, the TKSA, calculates the electrostatic free energy of the protein in the native state via the Tanford-Kirkwood approach for each residue. The other one, CpHMD-SBM, uses a Coulomb screening potential in addition to the structure-based model C
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