Evidence map›Paper›PMID 29320632›Full record

ArticleBiochemistry2018

Increasing the Stability of Recombinant Human Green Cone Pigment.

Timothy S Owen, David Salom, Wenyu Sun, Krzysztof Palczewski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. A short story on how chromophore is hydrolyzed from rhodopsin for recycling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Review
  4. Review
  5. Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Human red and green cone opsins areThe Journal of biological chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Timothy S OwenDepartment of Pharmacology, Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University , 2109 Adelbert Road, Cleveland, Ohio 44106, United States.
David SalomDepartment of Pharmacology, Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University , 2109 Adelbert Road, Cleveland, Ohio 44106, United States.
Wenyu SunPolgenix, Inc. , Cleveland, Ohio 44106, United States.
Krzysztof PalczewskiDepartment of Pharmacology, Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University , 2109 Adelbert Road, Cleveland, Ohio 44106, United States.ORCID 0000-0002-0788-545X
Case Western Reserve University · USPolgenix (United States) · US

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
Novel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
NEI NIH HHS R01 EY009339NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283
6 · The paper itself

Abstract

Three types of cone cells exist in the human retina, each containing a different pigment responsible for the initial step of phototransduction. These pigments are distinguished by their specific absorbance maxima: 425 nm (blue), 530 nm (green), and 560 nm (red). Each pigment contains a common chromophore, 11-cis-retinal covalently bound to an opsin protein via a Schiff base. The 11-cis-retinal protonated Schiff base has an absorbance maxima at 440 nm in methanol. Unfortunately, the chemistry that allows the same chromophore to interact with different opsin proteins to tune the absorbance of the resulting pigments to distinct λ

Indexed as

AnimalsArchaeal ProteinsCarrier ProteinsHumansModels, MolecularProtein ConformationProtein StabilityPyrococcus abyssiRecombinant Fusion ProteinsRetinaldehydeRod OpsinsSf9 CellsTemperature11-cis-retinal-binding proteinArchaeal ProteinsCarrier Proteinsmiddle-wavelength opsinRecombinant Fusion ProteinsRetinaldehydeRod Opsins

Identifiers

PMID29320632
PMCPMC5853123
OpenAlexW2783539130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.