ArticlePediatric research2018
Brain growth in the NICU: critical periods of tissue-specific expansion.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06052865 (Serial Neuroimaging of Brain Injury and Brain Growth in the NICU in the Very Preterm Infant), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serial Neuroimaging of Brain Injury and Brain Growth in the NICU in the Very Preterm Infant
Who cites it
36 citing papers in PubMed, 46 citations in OpenAlex.
- A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR.Scientific reports · 2021Trial
- Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancy.Gut microbes · 2026Article
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Associations of human milk lactoferrin with measures of physical growth in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Tracing the early bacterial settlers in preterm and very-low birth-weight infants: first report of microbiota dynamics in South American neonates.Infection and immunity · 2026Article
- The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling : MRI study.Scientific reports · 2025Article
- Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies.Frontiers in human neuroscience · 2025Review
- A Simple MRI Score Predicts Pathological General Movements in Very Preterm Infants with Brain Injury-Retrospective Cohort Study.Children (Basel, Switzerland) · 2024Article
- Impact of Nutritional Status on Total Brain Tissue Volumes in Preterm Infants.Children (Basel, Switzerland) · 2024Article
- Associations between gut microbiota and adverse neurodevelopmental outcomes in preterm infants: a two-sample Mendelian randomization study.Frontiers in neuroscience · 2024Article
- Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits.BMC medicine · 2023Article
- Article
- Early-life gut microbiota and neurodevelopment in preterm infants: a narrative review.Frontiers in nutrition · 2023Review
- Serial neuroimaging of brain growth and development in very preterm infants receiving tailored neuropromotive support in the NICU. Protocol for a prospective cohort study.Frontiers in pediatrics · 2023Article
- Neurobehavior in very preterm infants with low medical risk and full-term infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- The transition to parenthood in obstetrics: enhancing prenatal care for 2-generation impact.American journal of obstetrics & gynecology MFM · 2022Review
- Seizure burden in preterm infants and smaller brain volume at term-equivalent age.Pediatric research · 2022Article
- Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.Frontiers in pharmacology · 2022Review
- Patterns of Fetal and Infant Growth and Brain Morphology at Age 10 Years.JAMA network open · 2021Article
- Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage.Cell host & microbe · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
ObjectiveTo examine, using serial magnetic resonance imaging (MRI), total and tissue-specific brain growth in very-preterm (VPT) infants during the period that coincides with the early and late stages of the third trimester.MethodsStructural MRI scans were collected from two prospective cohorts of VPT infants (≤30 weeks of gestation). A total of 51 MRI scans from 18 VPT subjects were available for volumetric analysis. Brain tissue was classified into cerebrospinal fluid, cortical gray matter, myelinated and unmyelinated white matter, deep nuclear gray matter, and cerebellum. Nine infants had sufficient serial scans to allow comparison of tissue growth during the periods corresponding to the early and late stages of the third trimester.ResultsTissue-specific differences in ex utero brain growth trajectories were observed in the period corresponding to the third trimester. Most notably, there was a marked increase in cortical gray matter expansion from 34 to 40 weeks of postmenstrual age, emphasizing this critical period of brain development.ConclusionUtilizing serial MRI to document early brain development in VPT infants, this study documents regional differences in brain growth trajectories ex utero during the period corresponding to the first and second half of the third trimester, providing novel insight into the maturational vulnerability of the rapidly expanding cortical gray matter in the NICU.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.