Evidence map›Paper›PMID 29320483›Full record

ArticlePediatric research2018

Microarray analysis in pregnancies with isolated unilateral kidney agenesis.

Lena Sagi-Dain, Idit Maya, Amir Peleg, Adi Reches, Ehud Banne, Hagit N Baris, Tamar Tenne, Amihood Singer, Shay Ben-Shachar

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Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lena Sagi-DainGenetics Institute, Carmel Medical Center, Haifa, Israel.
Idit MayaRecanati Genetics Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel.
Amir PelegGenetics Institute, Carmel Medical Center, Haifa, Israel.
Adi RechesGenetics Institute, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ehud BanneThe Genetic Institute, Kaplan Medical Center, Rehovot, Israel.
Hagit N BarisThe Genetics Institute, Rambam Health Care Campus, Haifa, Israel.
Tamar TenneMedical Genetics Institute, Meir Medical Center, Kfar Saba, Israel.
Amihood SingerCommunity Genetics, Public Health Services, Ministry of Health, Jerusalem, Israel.
Shay Ben-ShacharGenetics Institute, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundThe objective of our study was to examine the risk for submicroscopic chromosomal aberrations among fetuses with apparently isolated solitary kidney.MethodsData acquisition was performed retrospectively by searching Israeli Ministry of Health-computerized database. All cases having chromosomal microarray analysis (CMA), referred because of an indication of isolated unilateral kidney agenesis between January 2013 and September 2016, were included. Rate of clinically significant CMA findings in these pregnancies was compared to pregnancies with normal ultrasound, based on a systematic review encompassing 9,792 cases and local data of 5,541 pregnancies undergoing CMA because of maternal request.ResultsOf the 81 pregnancies with isolated solitary kidney, 2 (2.47%) loss-of-copy number variants compatible with well-described deletion syndromes were reported (16p11.2-16p12.2 and 22q11.21 microdeletion syndromes). In addition, one variant of unknown significance was demonstrated. The relative risk for pathogenic CMA findings among pregnancies with isolated unilateral renal agenesis was not significantly different compared with the control population.ConclusionCMA analysis in pregnancies with unilateral renal agenesis might still be useful, to the same degree as it can be in the general population.

Indexed as

Oligonucleotide Array Sequence AnalysisAdultChromosome AberrationsChromosome DeletionChromosomes, Human, Pair 16Chromosomes, Human, Pair 22FemaleGenetic Association StudiesHumansKidneyMaleMaternal AgePregnancyRetrospective StudiesRiskSolitary Kidney

Identifiers

PMID29320483

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.