ArticlePediatric research2018
Severe retinopathy of prematurity is associated with reduced cerebellar and brainstem volumes at term and neurodevelopmental deficits at 2 years.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Retinopathy of Prematurity Is Associated With Reduced Thalamic Volume and Impaired Neurodevelopment. A Cohort Study.Journal of paediatrics and child health · 2026Article
- Polyunsaturated Fatty Acid Balance Modulates Microglial State in a Murine Model of Oxygen-Induced Neovascularization.Nutrients · 2026Article
- Article
- Retinopathy of Prematurity and Risk of Structural Brain Abnormalities on Magnetic Resonance Imaging at Term Among Infants Born at Less Than or Equal to 32 Weeks of Gestation.The Journal of pediatrics · 2025Article
- Polyunsaturated fatty acid balance modulates microglial state in a murine model of oxygen-induced neovascularization.Research square · 2025Article
- Increased risk of autism in extremely preterm children with a history of retinopathy of prematurity.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Association between severe retinopathy of prematurity (ROP) and poor motor neurodevelopmental outcome.Indian journal of ophthalmology · 2023Review
- Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Neurosensory Alterations in Retinopathy of Prematurity: A Window to Neurological Impairments Associated to Preterm Birth.Biomedicines · 2022Review
- Early versus later initiation of parenteral nutrition for very preterm infants: a propensity score-matched observational study.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Severe Retinopathy of Prematurity Associated With Neurodevelopmental Disorder in Children.Frontiers in pediatrics · 2022Article
- Association of Severe Retinopathy of Prematurity and Bronchopulmonary Dysplasia with Adverse Neurodevelopmental Outcomes in Preterm Infants without Severe Brain Injury.Brain sciences · 2021Article
- Severe Retinopathy of Prematurity Is Not Independently Associated With Worse Neurodevelopmental Outcomes in Preterm Neonates.Frontiers in pediatrics · 2021Article
- High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks.BMJ open ophthalmology · 2021Article
- Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.Scientific reports · 2019Article
- Automatic extraction of the intracranial volume in fetal and neonatal MR scans using convolutional neural networks.NeuroImage. Clinical · 2019Article
- Infant Brain Structural MRI Analysis in the Context of Thoracic Non-cardiac Surgery and Critical Care.Frontiers in pediatrics · 2019Article
- Fetal Growth Restriction Alters Cerebellar Development in Fetal and Neonatal Sheep.Frontiers in physiology · 2019Article
- Visual Maturation at Term Equivalent Age in Very Premature Infants According to Factors Influencing Its Development.Frontiers in physiology · 2018Article
- Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants.Neonatology · 2018Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundTo evaluate the association between severe retinopathy of prematurity (ROP), measures of brain morphology at term-equivalent age (TEA), and neurodevelopmental outcome.MethodsEighteen infants with severe ROP (median gestational age (GA) 25.3 (range 24.6-25.9 weeks) were included in this retrospective case-control study. Each infant was matched to two extremely preterm control infants (n=36) by GA, birth weight, sex, and brain injury. T2-weighted images were obtained on a 3 T magnetic resonance imaging (MRI) at TEA. Brain volumes were computed using an automatic segmentation method. In addition, cortical folding metrics were extracted. Neurodevelopment was formally assessed at the ages of 15 and 24 months.ResultsInfants with severe ROP had smaller cerebellar volumes (21.4±3.2 vs. 23.1±2.6 ml; P=0.04) and brainstem volumes (5.4±0.5 ml vs. 5.8±0.5 ml; P=0.01) compared with matched control infants. Furthermore, ROP patients showed a significantly lower development quotient (Griffiths Mental Development Scales) at the age of 15 months (93±15 vs. 102±10; P=0.01) and lower fine motor scores (10±3 vs. 12±2; P=0.02) on Bayley Scales (Third Edition) at the age of 24 months.ConclusionSevere ROP was associated with smaller volumes of the cerebellum and brainstem and with poorer early neurodevelopmental outcome. Follow-up through childhood is needed to evaluate the long-term consequences of our findings.
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