ArticleNature2018
An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 137 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EffectorK, a comprehensive resource to mine for Ralstonia, Xanthomonas, and other published effector interactors in the Arabidopsis proteome.Molecular plant pathology · 2020Pooled it
- NIK receptor kinases propagate phytocytokine-triggered immunity by driving early phosphorylation events.Nature plants · 2026Article
- Structure of the Arabidopsis receptor kinase SRF6 ectodomain determined from crystals obtained using the LRR crystallization screen.Acta crystallographica. Section D, Structural biology · 2026Article
- A receptor kinase complex refines cambium activity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Nematode extracellular protein interactome expands connections between signaling pathways.Cell genomics · 2026Article
- IMK2-IMK3 module regulates biogenesis of nascent cell walls and postcytokinetic differentiation inScience advances · 2026Article
- The chitin receptor-interacting protein LIK1 regulates extracellular ATP signaling via interaction with P2K1 inbioRxiv : the preprint server for biology · 2026Article
- Comparative proteomic profiling of receptor kinase signaling reveals key trafficking components enforcing plant stomatal development.Science advances · 2026Article
- Article
- SERK5 genetically compensates for the loss of BAK1 and BKK1 in regulating elf18-triggered immune signaling inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Specificity of brassinosteroid perception and its integration at signaling crossroads in vascular development.The Plant journal : for cell and molecular biology · 2025Review
- Overexpression of the Receptor-Like Kinase BIR1 Causes SOBIR1- and EDS1-Dependent Cell Death Phenotypes in Arabidopsis.Plant, cell & environment · 2025Article
- Comparative Proteomic Profiling of Receptor Kinase Signaling Reveals Key Trafficking Components Enforcing Plant Stomatal Development.bioRxiv : the preprint server for biology · 2025Article
- Flagellin sensing, signaling, and immune responses in plants.Plant communications · 2025Review
- Receptor-like kinases BIR1 and BIR3 modulate antiviral resistance by different mechanisms.The New phytologist · 2025Article
- Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat.Nature genetics · 2025Article
- The immune NIK1/RPL10/LIMYB signaling module regulates photosynthesis and translation under biotic and abiotic stresses.Nature communications · 2025Article
- Arabidopsis research in 2030: Translating the computable plant.The Plant journal : for cell and molecular biology · 2025Review
- LRR-RLK subfamily II of coreceptors: emerging, non-canonical and canonical roles in plant antiviral immunity and development.Frontiers in plant science · 2025Review
- The receptor MIK2 interacts with the kinase RKS1 to control quantitative disease resistance to Xanthomonas campestris.Plant physiology · 2024Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byAntenna network.2018
- Commented on by
- Erratum issued
Authors and funding
22 authors.
Funding
Abstract
The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor activation. Understanding how interactions between ECDs produce signal-competent receptor complexes is challenging because of their low biochemical tractability. In plants, the discovery of ECD interactions is complicated by the massive expansion of receptor families, which creates tremendous potential for changeover in receptor interactions. The largest of these families in Arabidopsis thaliana consists of 225 evolutionarily related leucine-rich repeat receptor kinases (LRR-RKs), which function in the sensing of microorganisms, cell expansion, stomata development and stem-cell maintenance. Although the principles that govern LRR-RK signalling activation are emerging, the systems-level organization of this family of proteins is unknown. Here, to address this, we investigated 40,000 potential ECD interactions using a sensitized high-throughput interaction assay, and produced an LRR-based cell surface interaction network (CSI
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.