Evidence map›Paper›PMID 29320407›Full record

ArticleInternational journal of molecular sciences2018

Biodistribution and Clearance of Stable Superparamagnetic Maghemite Iron Oxide Nanoparticles in Mice Following Intraperitoneal Administration.

Binh T T Pham, Emily K Colvin, Nguyen T H Pham, Byung J Kim, Emily S Fuller, Elizabeth A Moon, Raphael Barbey, Samuel Yuen, Barry H Rickman, Nicole S Bryce and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 96 citations in OpenAlex.

  1. Review
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  3. Effect of clinically relevant iron oxide nanoparticles on macrophage polarization, tumor growth and tumor microenvironment modulation.Journal of controlled release : official journal of the Controlled Release Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Binh T T PhamKey Centre for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia. phamthuybinh@yahoo.com.
Emily K ColvinBill Walsh Translational Cancer Research Laboratory, Kolling Institute, Royal North Shore Hospital, Sydney, NSW 2065, Australia. emily.colvin@sydney.edu.au.
Nguyen T H PhamKey Centre for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia. nguyen.pham@sydney.edu.au.
Byung J KimKey Centre for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia. Bkim5239@gmail.com.
Emily S FullerBill Walsh Translational Cancer Research Laboratory, Kolling Institute, Royal North Shore Hospital, Sydney, NSW 2065, Australia. emily.fuller@sydney.edu.au.
Elizabeth A MoonBill Walsh Translational Cancer Research Laboratory, Kolling Institute, Royal North Shore Hospital, Sydney, NSW 2065, Australia. e.millar@sydney.edu.au.
Raphael BarbeyKey Centre for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia. raphael.barbey@a3.epfl.ch.
Samuel YuenBill Walsh Translational Cancer Research Laboratory, Kolling Institute, Royal North Shore Hospital, Sydney, NSW 2065, Australia. samuel.yuen@sydney.edu.au.
Barry H RickmanSydney School of Veterinary Science, University of Sydney Teaching Hospital Camden, Camden, NSW 2570, Australia. barry.rickman@gmail.com.
Nicole S BryceKey Centre for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia. nicole.bryce@unsw.edu.au.
Stephanie BickleySirtex Medical Limited, North Sydney, NSW 2060, Australia. s_rozeleur@hotmail.com.
Marcel TanudjiSirtex Medical Limited, North Sydney, NSW 2060, Australia. mtanudji@sirtex.com.
Stephen K JonesSirtex Medical Limited, North Sydney, NSW 2060, Australia. skjones314@gmail.com.
Viive M HowellBill Walsh Translational Cancer Research Laboratory, Kolling Institute, Royal North Shore Hospital, Sydney, NSW 2065, Australia. viive.howell@sydney.edu.au.
Brian S HawkettKey Centre for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia. brian.hawkett@sydney.edu.au.
The University of Sydney · AUSirtex (Australia) · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomedicine is an emerging field with great potential in disease theranostics. We generated sterically stabilized superparamagnetic iron oxide nanoparticles (s-SPIONs) with average core diameters of 10 and 25 nm and determined the in vivo biodistribution and clearance profiles. Healthy nude mice underwent an intraperitoneal injection of these s-SPIONs at a dose of 90 mg Fe/kg body weight. Tissue iron biodistribution was monitored by atomic absorption spectroscopy and Prussian blue staining. Histopathological examination was performed to assess tissue toxicity. The 10 nm s-SPIONs resulted in higher tissue-iron levels, whereas the 25 nm s-SPIONs peaked earlier and cleared faster. Increased iron levels were detected in all organs and body fluids tested except for the brain, with notable increases in the liver, spleen, and the omentum. The tissue-iron returned to control or near control levels within 7 days post-injection, except in the omentum, which had the largest and most variable accumulation of s-SPIONs. No obvious tissue changes were noted although an influx of macrophages was observed in several tissues suggesting their involvement in s-SPION sequestration and clearance. These results demonstrate that the s-SPIONs do not degrade or aggregate in vivo and intraperitoneal administration is well tolerated, with a broad and transient biodistribution. In an ovarian tumor model, s-SPIONs were shown to accumulate in the tumors, highlighting their potential use as a chemotherapy delivery agent.

Indexed as

AnimalsCell Line, TumorCell SurvivalFerric CompoundsForkhead Transcription FactorsHumansInjections, IntraperitonealLiverMacrophagesMagnetite NanoparticlesMiceMice, Inbred BALB CMice, KnockoutMice, NudeOmentumParticle SizeFerric Compoundsferric oxideForkhead Transcription FactorsMagnetite NanoparticlesWhn protein

Identifiers

PMID29320407
PMCPMC5796154
OpenAlexW2783212216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.