ReviewHormone molecular biology and clinical investigation2018
Cardiometabolic effects of psychotropic medications.
Review in Hormone molecular biology and clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05157386 (Physical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety - a Retrospective Study of the Braining Project 2017-2020 Regarding Feasibility, Participants and Changes in Symptoms, Function and Physical Parameters), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety - a Retrospective Study of the Braining Project 2017-2020 Regarding Feasibility, Participants and Changes in Symptoms, Function and Physical Parameters
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- White matter hyperintensities in bipolar disorder: systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Unmet challenges in treating hypertension in patients with borderline personality disorder: A systematic review.Medicine · 2019Pooled it
- Trial
- Mechanisms of weight gain associated with valproic acid: a scoping review.European archives of psychiatry and clinical neuroscience · 2026Article
- Appraising the Quality of Patient Decision Aids for Brain and Heart Health: An Environmental Scan with a Health Equity Lens.CJC open · 2026Article
- Psychotropic drug-induced weight gain and untargeted metabolomics: machine learning-driven results from a prospective cohort study.Translational psychiatry · 2026Article
- Prevalence of chronic kidney disease in people with severe mental illness: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science · 2026Review
- A five-year risk prediction model of cardiovascular disease in individuals with bipolar disorder: a nationwide register study from Sweden.Molecular psychiatry · 2026Article
- Managing metabolic syndrome in bipolar disorder: multidisciplinary monitoring and treatment strategies.Frontiers in psychiatry · 2026Review
- Decoding psychotropic-induced metabolic disturbances: gut-brain axis, multi-omics, and nutrition-lifestyle integration.Frontiers in nutrition · 2026Review
- Ultra-High Performance Liquid Chromatography Mass Spectrometry-based Metabolic Profiling in Urine for Bipolar Disorder with Manic Episode.Noro psikiyatri arsivi · 2026Article
- Psychiatric Comorbidity and Metabolic Heterogeneity in a Multimorbid Cardiometabolic Cohort: An Exploratory Real-World Analysis.Healthcare (Basel, Switzerland) · 2025Article
- The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options.International journal of bipolar disorders · 2025Review
- Long term outcomes after COVID-19 in patients with schizophrenia: a historical cohort study in a health maintenance organization.Social psychiatry and psychiatric epidemiology · 2025Article
- Risk of Cardiovascular Disease Associated with Serious Mental Illness among People of African Ancestry.Ethnicity & disease · 2025Article
- An analysis on the role of glucagon-like peptide 1 receptor agonists in cognitive and mental health disorders.Nature. Mental health · 2025Article
- Psychotropic Medication Use in Children and Youth with Autism Enrolled in Medicaid.Journal of autism and developmental disorders · 2025Article
- The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.PloS one · 2025Article
- Beyond the Brain: The Physical Health and Whole-Body Impact of Fetal Alcohol Spectrum Disorders.Alcohol research : current reviews · 2025Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Background Many psychiatric disorders including schizophrenia, bipolar disorder and major depression convey an excess burden of cardiovascular morbidity and mortality. The medications used to treat these conditions may further adversely affect cardiovascular risk and exacerbate health disparities for vulnerable populations. There is a clinical need to appreciate the cardiometabolic adverse effects of psychotropic medications. Methods This paper reviews the most relevant cardiometabolic effects of psychotropic medications, organized around the components of metabolic syndrome. When known, the molecular and physiological mechanisms underlying any adverse cardiometabolic effects are detailed. Results Many commonly used psychotropic medications, particularly antipsychotics, mood stabilizers and some antidepressants, have been independently associated with cardiometabolic risk factors such as insulin resistance, obesity and dyslipidemia. Stimulants, antidepressants that inhibit reuptake of norepinephrine, some antipsychotics and valproic acid derivatives may also increase blood pressure. Conclusion Understanding, assessing and subsequently managing cardiometabolic complications of psychotropic medications are important to mitigate the excess cardiovascular morbidity and mortality in the clinical populations prescribed psychotropic medications. There is considerable variability in risk between medications and individuals. Timely management of iatrogenic cardiometabolic effects is critical.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.