Evidence map›Paper›PMID 29320154›Full record

ArticleACS applied materials & interfaces2018

High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.

Belén Rubio-Ruiz, Ana M Pérez-López, Thomas L Bray, Martin Lee, Alan Serrels, Martín Prieto, Manuel Arruebo, Neil O Carragher, Víctor Sebastián, Asier Unciti-Broceta

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Effect of the Size and Shape of Ho, Tm:KLu(WONanomaterials (Basel, Switzerland) · 2021
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Belén Rubio-RuizCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Ana M Pérez-LópezCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Thomas L BrayCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Martin LeeCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Alan SerrelsMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh , Edinburgh EH16 4TJ, United Kingdom.
Martín PrietoDepartment of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza , Campus Río Ebro-Edificio I+D, c/Poeta Mariano Esquillor s/n, 50018 Zaragoza, Spain.
Manuel ArrueboDepartment of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza , Campus Río Ebro-Edificio I+D, c/Poeta Mariano Esquillor s/n, 50018 Zaragoza, Spain.ORCID http://orcid.org/0000-0003-3165-0156
Neil O CarragherCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Víctor SebastiánDepartment of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza , Campus Río Ebro-Edificio I+D, c/Poeta Mariano Esquillor s/n, 50018 Zaragoza, Spain.ORCID http://orcid.org/0000-0002-6873-5244
Asier Unciti-BrocetaCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.ORCID http://orcid.org/0000-0003-1029-2855
Edinburgh Cancer Research · GBUniversidad de Zaragoza · ESQueen's Medical Centre · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Herein, we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labeled cancer cells upon short exposure to near-infrared (NIR) light. Following cell treatment with Pd-NPs, ablated areas were patterned with high precision by laser scanning microscopy, allowing one to perform cell migration assays with unprecedented accuracy. Using coherent Raman microscopy, cells containing Pd-NPs were simultaneously ablated and imaged. This novel methodology was combined with intravital imaging to mediate microablation of cancerous tissue in tumor xenografts in mice.

Indexed as

Metal NanoparticlesAnimalsMiceMicroscopy, ConfocalNeoplasmsPalladiumPhototherapyPalladiumbioorthogonalCARSlaser scanning microscopynanoparticlespalladiumphotothermal effect

Identifiers

PMID29320154
PMCPMC5799879
OpenAlexW2782796384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.