ArticleAlzheimer disease and associated disorders
Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07284316 (Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance: A Randomized Clinical Trial
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of CPAP duration and adherence for cognitive improvement in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Prevalence of dementia in Latin America and Caribbean countries: Systematic review and meta-analyses exploring age, sex, rurality, and education as possible determinants.Ageing research reviews · 2022Pooled it
- Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.Nature aging · 2026Review
- Dementia Is Associated with In-Hospital Mortality and Prolonged Length of Stay: A Propensity Score Matched Analysis on Administrative Data.Healthcare (Basel, Switzerland) · 2025Article
- Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort.Alzheimer's research & therapy · 2025Article
- Heterogeneity in cognitive profiles of monolingual and bilingual Hispanic/Latino older adults in HABS-HD.Journal of the International Neuropsychological Society : JINS · 2024Article
- [Cognitive function groups in older people and risk factors].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Racial, Ethnic, and Geographic Diversity in Population Neuroscience.Current topics in behavioral neurosciences · 2024Review
- Discordant Biological and Chronological Age: Implications for Cognitive Decline and Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Investigating the factors that explain white matter hyperintensity load in older Indians.Brain communications · 2023Article
- A training program for researchers in population neuroimaging: Early experiences.Frontiers in neuroimaging · 2022Review
- Detecting Suicide Ideation in the Era of Social Media: The Population Neuroscience Perspective.Frontiers in psychiatry · 2022Article
- Population Neuroscience: An Arranged Marriage.Annals of neurosciences · 2022Article
- A guide for researchers seeking training in retrospective data harmonization for population neuroscience studies of Alzheimer's disease and related dementias.Frontiers in neuroimaging · 2022Article
- Vascular cognitive impairment and dementia: An early career researcher perspective.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Hierarchical modelling of functional brain networks in population and individuals from big fMRI data.NeuroImage · 2021Article
- Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study.Brain imaging and behavior · 2021Article
- Article
- Alzheimer's disease pathology in a community-based sample of older adults without dementia: The MYHAT neuroimaging study.Brain imaging and behavior · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Over recent decades, epidemiology has made significant contributions to our understanding of dementia, translating scientific discoveries into population health. Here, we propose reframing dementia epidemiology as "population neuroscience," blending techniques and models from contemporary neuroscience with those of epidemiology and biostatistics. On the basis of emerging evidence and newer paradigms and methods, population neuroscience will minimize the bias typical of traditional clinical research, identify the relatively homogenous subgroups that comprise the general population, and investigate broader and denser phenotypes of dementia and cognitive impairment. Long-term follow-up of sufficiently large study cohorts will allow the identification of cohort effects and critical windows of exposure. Molecular epidemiology and omics will allow us to unravel the key distinctions within and among subgroups and better understand individuals' risk profiles. Interventional epidemiology will allow us to identify the different subgroups that respond to different treatment/prevention strategies. These strategies will inform precision medicine. In addition, insights into interactions between disease biology, personal and environmental factors, and social determinants of health will allow us to measure and track disease in communities and improve population health. By placing neuroscience within a real-world context, population neuroscience can fulfill its potential to serve both precision medicine and population health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.