Evidence map›Paper›PMID 29319471›Full record

ArticleMicrobial genomics2018

MentaLiST - A fast MLST caller for large MLST schemes.

Pedro Feijao, Hua-Ting Yao, Dan Fornika, Jennifer Gardy, William Hsiao, Cedric Chauve, Leonid Chindelevitch

Abstract read
In one paragraph

Article in Microbial genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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  5. Genomic Epidemiology of Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pedro Feijao1​School of Computing Science, Simon Fraser University, Vancouver, Canada.
Hua-Ting Yao2​École Polytechnique, Université Paris-Saclay, Palaiseau, France.
Dan Fornika3​BC Centre for Disease Control, Vancouver, Canada.
Jennifer Gardy4​School of Population and Public Health, University of British Columbia, Vancouver, Canada.
William Hsiao5​Department of Pathology and Laboratory Medicine, University of British Columbia and BC Centre for Disease Control, Vancouver, Canada.
Cedric Chauve6​Department of Mathematics, Simon Fraser University, Vancouver, Canada.
Leonid Chindelevitch1​School of Computing Science, Simon Fraser University, Vancouver, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MLST (multi-locus sequence typing) is a classic technique for genotyping bacteria, widely applied for pathogen outbreak surveillance. Traditionally, MLST is based on identifying sequence types from a small number of housekeeping genes. With the increasing availability of whole-genome sequencing data, MLST methods have evolved towards larger typing schemes, based on a few hundred genes [core genome MLST (cgMLST)] to a few thousand genes [whole genome MLST (wgMLST)]. Such large-scale MLST schemes have been shown to provide a finer resolution and are increasingly used in various contexts such as hospital outbreaks or foodborne pathogen outbreaks. This methodological shift raises new computational challenges, especially given the large size of the schemes involved. Very few available MLST callers are currently capable of dealing with large MLST schemes. We introduce MentaLiST, a new MLST caller, based on a k-mer voting algorithm and written in the Julia language, specifically designed and implemented to handle large typing schemes. We test it on real and simulated data to show that MentaLiST is faster than any other available MLST caller while providing the same or better accuracy, and is capable of dealing with MLST schemes with up to thousands of genes while requiring limited computational resources. MentaLiST source code and easy installation instructions using a Conda package are available at https://github.com/WGS-TB/MentaLiST.

Indexed as

BacteriaBacterial Typing TechniquesDisease OutbreaksEnterococcus faeciumEpidemiological MonitoringFoodborne DiseasesGenes, EssentialGenome, BacterialHumansMolecular EpidemiologyMultilocus Sequence TypingMycobacterium tuberculosisSalmonellaSoftwareTime FactorsWhole Genome Sequencingmulti-locus sequence typingnext-generation sequencingpathogen surveillance

Identifiers

PMID29319471
PMCPMC5857373

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.