Evidence map›Paper›PMID 29319186›Full record

ArticleThe Journal of physiology2018

The large-conductance voltage- and Ca

Ramón A Lorca, Monali Wakle-Prabagaran, William E Freeman, Meghan K Pillai, Sarah K England

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. CaInternational journal of molecular sciences · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Preeclampsia link to gestational hypoxia.Journal of developmental origins of health and disease · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ramón A LorcaCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, 63110, USA.ORCID 0000-0002-7330-6284
Monali Wakle-PrabagaranCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, 63110, USA.
William E FreemanCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, 63110, USA.ORCID 0000-0001-9474-418X
Meghan K PillaiCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, 63110, USA.
Sarah K EnglandCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, 63110, USA.
Washington University in St. Louis · US

Funding

REGULATION OF UTERINE SMOOTH MUSCLE EXCITABILITYR01HD037831 · NICHD · WASHINGTON UNIVERSITY · PI ENGLAND, SARAH K. · 1999 to 2023
$7.0M
Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growthR01HD088590 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Colleen Glyde Julian, LORNA G. MOORE · 2016 to 2026
$4.3M
American Heart Association-American Stroke Association 12POST10660000NICHD NIH HHS R01 HD037831NICHD NIH HHS R01 HD088590
6 · The paper itself

Abstract

key pointsThe uterine artery (UA) markedly vasodilates during pregnancy to direct blood flow to the developing fetus. Inadequate UA vasodilatation leads to intrauterine growth restriction and fetal death. The large-conductance voltage- and Ca ABSTRACT: Insufficient vasodilatation of the uterine artery (UA) during pregnancy leads to poor utero-placental perfusion, contributing to intrauterine growth restriction and fetal loss. Activity of the large-conductance Ca

Indexed as

VasodilationAnimalsArteriesFemaleFetusLarge-Conductance Calcium-Activated Potassium ChannelsMiceMice, KnockoutMuscle, Smooth, VascularPregnancyProtein SubunitsUterusLarge-Conductance Calcium-Activated Potassium ChannelsProtein Subunitsauxiliary subunitsBKCa channelpregnancyuterine arteryutero-placental perfusionvascular smooth muscle

Identifiers

PMID29319186
PMCPMC5851882
OpenAlexW2783488737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.