Evidence map›Paper›PMID 29318567›Full record

ReviewSleep & breathing = Schlaf & Atmung2018

Phenotyping the pathophysiology of obstructive sleep apnea using polygraphy/polysomnography: a review of the literature.

Marcello Bosi, Andrea De Vito, Bhik Kotecha, Luca Viglietta, Alberto Braghiroli, Joerg Steier, Martino Pengo, Giovanni Sorrenti, Riccardo Gobbi, Claudio Vicini and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sleep & breathing = Schlaf & Atmung, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Maximizing outcomes by multimodal treatment in obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. [Effects of orofacial myofunctional therapy on postoperative outcomes of upper airway surgery for adults with severe obstructive sleep apnea].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Trial
  4. Trial
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  9. Article
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  12. Observational
  13. Article
  14. Review
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  17. DISE with CPAP: a useful procedure to evaluate upper airway collapsibility.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Observational
  18. Article
  19. Craniofacial morphology in Obstructive Sleep Apnea patients.Journal of clinical and experimental dentistry · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcello BosiAUSL of Romagna, Department Thoracic Diseases, Pulmonary Operative Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.
Andrea De VitoAUSL of Romagna, Head and Neck Department, ENT Unit, Morgagni-Pierantoni Hospital, Via Dei Gerolimini 12, 47121, Forlì, Italy. dr.andrea.devito@gmail.com.ORCID http://orcid.org/0000-0002-9802-7716
Bhik KotechaDepartment of Otolaryngology-Head and Neck Surgery, Royal National Throat, Nose and Ear Hospital, London, UK.
Luca VigliettaAUSL of Romagna, Department of Thoracic Diseases, Pulmonary Operative Unit, Umberto I Hospital, Lugo, Italy.
Alberto BraghiroliDepartment of Pulmonary Rehabilitation, Sleep Laboratory, Istituti Clinici Scientifici Maugeri, SPA SB, IRCCS, Veruno, Italy.
Joerg SteierFaculty of Life Sciences and Medicine, King's College London, London, UK.
Martino PengoLane Fox Respiratory Unit/Sleep Disorders Centre, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Giovanni SorrentiAOU of Bologna, ENT Clinic, Faculty of Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
Riccardo GobbiAUSL of Romagna, Head and Neck Department, ENT Unit, Morgagni-Pierantoni Hospital, Via Dei Gerolimini 12, 47121, Forlì, Italy.
Claudio ViciniAUSL of Romagna, Department Thoracic Diseases, Pulmonary Operative Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.
Venerino PolettiAUSL of Romagna, Department Thoracic Diseases, Pulmonary Operative Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous positive airway pressure (CPAP) is the first-line treatment for the majority of patients affected by obstructive sleep apnea syndrome (OSA). However, long-term compliance with CPAP therapy may result limited and alternatives to CPAP therapy are required to address the increasing need to provide tailored therapeutic options. Understanding the pathophysiological traits (PTs) of OSA patients [upper airway (UA) anatomical collapsibility, loop gain (LG), arousal threshold (AT), and UA gain (UAG)] lies at the heart of the customized OSA treatment. However, sleep research laboratories capable to phenotype OSA patients are sparse and the diagnostic procedures time-consuming, costly, and requiring significant expertise. The question arises whether the use of routine clinical polysomnography or nocturnal portable multi-channel monitoring (PSG/PM) can provide sufficient information to characterize the above traits. The aim of the present review is to deduce if the information obtainable from the clinical PSG/PM analysis, independently of the scope and context of the original studies, is clinically useful to define qualitatively the PTs of individual OSA patients. In summary, it is possible to identify four patterns using PSG/PM that are consistent with an altered UA collapsibility, three that are consistent with altered LG, two with altered AT, and three consistent with flow limitation/UA muscle response. Furthermore, some PSG/PM indexes and patterns, useful for the suitable management of OSA patient, have been discussed. The delivery of this clinical approach to phenotype pathophysiological traits will allow patients to benefit in a wider range of sleep services by facilitating tailored therapeutic options.

Indexed as

PhenotypePolysomnographyArousalHumansPrecision MedicineSleepSleep Apnea, ObstructiveClinical PSG/PM analysisCustomized OSA therapyObstructive sleep apnea syndromePathophysiologic trait

Identifiers

PMID29318567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.