Evidence map›Paper›PMID 29318432›Full record

ArticleEuropean radiology2018

The PRICE study: The role of conventional and diffusion-weighted magnetic resonance imaging in assessment of locally advanced cervical cancer patients administered by chemoradiation followed by radical surgery.

A L Valentini, M Miccò, B Gui, M Giuliani, E Rodolfino, A M Telesca, T Pasciuto, A Testa, M A Gambacorta, G Zannoni and 5 more

Abstract read
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In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Which is the best timing to assess response after chemoradiation in locally advanced cervical cancer (BRILACC)?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
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  12. The role ofEuropean journal of nuclear medicine and molecular imaging · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

A L ValentiniDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
M MiccòDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
B GuiDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy. benedetta.gui@policlinicogemelli.it.ORCID http://orcid.org/0000-0002-5130-2100
M GiulianiDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
E RodolfinoDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
A M TelescaDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
T PasciutoDepartment of Gynecology and Obstetrics, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
A TestaDepartment of Gynecology and Obstetrics, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
M A GambacortaDepartment of Radiotherapy, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
G ZannoniDepartment of Histopathology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
V RufiniDepartment of Nuclear Medicine, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
A GiordanoDepartment of Nuclear Medicine, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
V ValentiniDepartment of Radiotherapy, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
G ScambiaDepartment of Gynecology and Obstetrics, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
R ManfrediDepartment of Radiology, Università Cattolica del Sacro Cuore, Fondazione Agostino Gemelli, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.
Università Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyse the role of DW-MRI in early prediction of pathologically-assessed residual disease in locally-advanced cervical cancer (LACC) treated with neoadjuvant chemoradiotherapy followed by radical surgery.

methodsBetween October 2010-June 2014, 108 women with histologically-proven cervical cancer were screened; 88 were included in this study. Tumour volume (TV) and ADC

resultsCR and PR were documented in 40 and 48 patients. At baseline-MRI, TV did not differ between groups. At early-MRI, TV was higher in PR than in CR (p=0.001). ΔTV reduction after treatment was lower in PR than in CR (63.6% vs. 81.1%; p=0.001). At baseline-MRI and early-MRI, ADC

conclusionsTV evaluated before and early after treatment could predict pathological response in LACC. ADC KEY POINTS: • Early-MRI tumour volume assessment could predict pathological response to nCRT in LACC. • Best cut-off for predicting pathological PR was ΔTV reduction of 73 %. • Early-MRI ADC

Indexed as

HysterectomyNeoplasm StagingTumor BurdenAdultAgedChemoradiotherapyCombined Modality TherapyDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMiddle AgedNeoadjuvant TherapyPostoperative CareProspective StudiesROC CurveChemoradiotherapy · Diffusion magnetic resonance imagingMagnetic resonance imagingTumour volumeUterine cervical neoplasms

Identifiers

PMID29318432
OpenAlexW2782617108

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.