ArticleJournal of the Association for Research in Otolaryngology : JARO2018
Oncomodulin Expression Reveals New Insights into the Cellular Organization of the Murine Utricle Striola.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Vestibular hair cell redundancy and the critical requirement of type I cells for balance maintenance.Cellular and molecular life sciences : CMLS · 2026Article
- Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Persistence of vestibular function in the absence of glutamatergic transmission from hair cells.Scientific reports · 2026Article
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- Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity.Journal of biomedical science · 2025Article
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- Characterization of 3,3'-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle.Frontiers in molecular neuroscience · 2024Article
- TMC function, dysfunction, and restoration in mouse vestibular organs.Frontiers in neurology · 2024Article
- The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function.Cellular and molecular life sciences : CMLS · 2023Article
- Article
- Vestibular physiology and function in zebrafish.Frontiers in cell and developmental biology · 2023Review
- Vestibular Organ Dissection and Whole-Mount Immunolabeling in Mouse.Bio-protocol · 2022Article
- What Is Parvalbumin for?Biomolecules · 2022Review
- The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Calretinin Immunoreactivity in the VIIIth Nerve and Inner Ear Endorgans ofFrontiers in neuroscience · 2021Article
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- Calbindin expression in adult vestibular epithelia.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.Neuroscience · 2019Article
- Multiscale modeling of mechanotransduction in the utricle.Journal of neurophysiology · 2019Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
Oncomodulin (OCM, aka β-parvalbumin) is an EF-hand calcium binding protein that is expressed in a restricted set of hair cells in the peristriolar region of the mammalian utricle. In the present study, we determined the topologic distribution of OCM among hair cell phenotypes to advance our understanding of the cellular organization of the striola and the relationship of these phenotypes with characteristics of tissue polarity. The distributions of OCM-positive (OCM+) hair cells were quantified in utricles of mature C57Bl/6 mice. Immunohistochemistry was conducted using antibodies to OCM, calretinin, and β3-tubulin. Fluorophore-conjugated phalloidin was used to label hair cell stereocilia, which provided the basis for determining hair cell counts and morphologic polarizations. We found OCM expression in striolar types I and II hair cells, though the distributions were dissimilar to the native striolar type I and II distributions, favoring type I hair cells. The distribution of OCM immunoreactivity among striolar type I hair cells also reflected nonrandom distribution among type I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.