ArticleThe journal of headache and pain2018
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study.
Article in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Family History of Cluster Headache: A Systematic Review.JAMA neurology · 2020Pooled it
- Prevalence of familial cluster headache: a systematic review and meta-analysis.The journal of headache and pain · 2020Pooled it
- No Association Between G1246A Polymorphism inFrontiers in genetics · 2020Pooled it
- Neurotransmitter Imbalance in Cluster Headache: A Systematic Review of Mechanisms and Therapeutic Targets.Pain and therapy · 2025Review
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- Article
- Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype.Journal of neurology · 2023Article
- Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan.The journal of headache and pain · 2022Article
- Genetic overlap between temporomandibular disorders and primary headaches: A systematic review.The Japanese dental science review · 2022Review
- VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case-Control Study in a Southeastern European Caucasian Population.Journal of molecular neuroscience : MN · 2022Article
- Evidence That HFE H63D Variant Is a Potential Disease Modifier in Cluster Headache.Journal of molecular neuroscience : MN · 2022Article
- The molecular clock gene cryptochrome 1 (Cephalalgia : an international journal of headache · 2021Article
- Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache.Annals of neurology · 2021Article
- Cluster headache and TACs: state of the art.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.Journal of molecular neuroscience : MN · 2020Article
- Anoctamin 3: A Possible Link between Cluster Headache and CaBrain sciences · 2019Article
- Article
- Update on the pathophysiology of cluster headache: imaging and neuropeptide studies.Journal of pain research · 2019Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirmed that the HCRTR2 (Hypocretin Receptor 2) SNP rs2653349, and the ADH4 (Alcohol Dehydrogenase 4) SNP rs1126671 and rs1800759 polymorphisms are linked to CH. In addition, the CLOCK (Circadian Locomotor Output Cycles Kaput) gene is becoming a research hotspot for CH due to encoding a transcription factor that serves as a basic driving force for circadian rhythm in humans. The purpose of this study was to evaluate the association between CH and the HCRTR2, ADH4 and CLOCK genes in a Chinese CH case-control sample.
methodsWe genotyped polymorphisms of nine single nucleotide polymorphisms (SNPs) in the HCRTR2, ADH4 and CLOCK genes to perform an association study on a Chinese Han CH case-control sample (112 patients and 192 controls),using Sequenom MALDI-TOF mass spectrometry iPLEX platform. The frequencies and distributions of genotypes and haplotypes were statistically compared between the case and control groups to identify associations with CH. The effects of SNPs on CH were further investigated by multiple logistic regression.
resultsThe frequency of the HCRTR2 SNP rs3800539 GA genotype was significantly higher in cases than in controls (48.2% vs.37.0%). The GA genotypes was associated with a higher CH risk (OR = 1.483, 95% CI: 0.564-3.387, p = 0.038), however, after Bonferroni correction, the association lost statistical significance. Haplotype analysis of the HCRTR2 SNPs showed that among eight haplotypes, only H1-GTGGGG was linked to a reduced CH risk (44.7% vs. 53.1%, OR = 0.689, 95% CI =0.491~0.966, p = 0.030). No significant association of ADH4, CLOCK SNPs with CH was statistically detected in the present study.
conclusionsAssociation between HCRTR2, ADH4,CLOCK gene polymorphisms and CH was not significant in the present study, however, haplotype analysis indicated H1-GTGGGG was linked to a reduced CH risk.
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