Evidence map›Paper›PMID 29318157›Full record

Trial reportJournal of diabetes research2017

Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes.

Gry Høst Dørflinger, Charlotte Brink Holt, Steffen Thiel, Jakob Appel Østergaard, Troels Krarup Hansen

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gry Høst DørflingerDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.ORCID 0000-0003-3699-6607
Charlotte Brink HoltDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.ORCID 0000-0002-7503-5879
Steffen ThielDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Jakob Appel ØstergaardDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.ORCID 0000-0002-9877-5327
Troels Krarup HansenDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.ORCID 0000-0002-0708-2868
Aarhus University Hospital · DKAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy. Recent findings show that pancreas transplantation reduces MBL concentration. Whether the increased MBL concentration is reversed by improved glycaemic control remains unknown. We investigated the effects of improved glycaemic control on MBL concentration in patients with type 1 diabetes.

methodsWe measured MBL, fructosamine, and HbA

resultsAfter initiation of insulin pump therapy, the total daily insulin dose was significantly reduced (from 51 ± 18 IE/day to 39 ± 13 IE/day,

conclusionsMBL concentration decreased following the initiation of insulin pump therapy in patients with type 1 diabetes and did not correlate with changes in glycaemic control.

Indexed as

AdultBlood GlucoseCalibrationDiabetes Mellitus, Type 1Dose-Response Relationship, DrugFemaleFollow-Up StudiesFructosamineGlycated HemoglobinHumansInsulinInsulin Infusion SystemsMaleMannose-Binding LectinMiddle AgedYoung AdultBlood GlucoseFructosamineGlycated Hemoglobinhemoglobin A1c protein, humanInsulinMannose-Binding Lectin

Identifiers

PMID29318157
PMCPMC5727755
OpenAlexW2769617507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.