Evidence map›Paper›PMID 29318154›Full record

ArticleBioMed research international2017

Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study.

Murni Nazira Sarian, Qamar Uddin Ahmed, Siti Zaiton Mat So'ad, Alhassan Muhammad Alhassan, Suganya Murugesu, Vikneswari Perumal, Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Jalifah Latip

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 1 synthesis or guideline pooled it, 367 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Comparative Metabolomics and Transcriptomics Analysis ofMolecules (Basel, Switzerland) · 2026
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  6. Promiscuous Transferases Malonylate Furaneol Glucoside inJournal of agricultural and food chemistry · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Multifaceted Biological Activity of Selected FlavoneInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Antidiabetic potential ofRSC advances · 2025
    Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Murni Nazira SarianDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Qamar Uddin AhmedDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.ORCID 0000-0003-0565-3222
Siti Zaiton Mat So'adDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Alhassan Muhammad AlhassanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Suganya MurugesuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Vikneswari PerumalDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Sharifah Nurul Akilah Syed MohamadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Alfi KhatibDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.ORCID 0000-0003-4547-1108
Jalifah LatipSchool of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), 46300 Bangi, Selangor, Malaysia.ORCID 0000-0002-9214-1251
International Islamic University Malaysia · MYNational University of Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS

Indexed as

FlavonoidsFree Radical ScavengersHypoglycemic AgentsStructure-Activity RelationshipFlavonoidsFree Radical ScavengersHypoglycemic Agents

Identifiers

PMID29318154
PMCPMC5727842
OpenAlexW2770796289

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.