Evidence map›Paper›PMID 29318000›Full record

ArticleJournal of tissue engineering

Methacrylated gelatin/hyaluronan-based hydrogels for soft tissue engineering.

Lukas Kessler, Sandra Gehrke, Marc Winnefeld, Birgit Huber, Eva Hoch, Torsten Walter, Ralf Wyrwa, Matthias Schnabelrauch, Malte Schmidt, Maximilian Kückelhaus and 3 more

Abstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Adipose Tissue Fibrosis: Mechanisms, Models, and Importance.International journal of molecular sciences · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lukas KesslerDepartment of Plastic Surgery and Burn Centre, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.
Sandra GehrkeResearch and Development, Beiersdorf AG, Hamburg, Germany.
Marc WinnefeldResearch and Development, Beiersdorf AG, Hamburg, Germany.
Birgit HuberInstitute for Interfacial Engineering and Plasma Technology, University of Stuttgart, Stuttgart, Germany.
Eva HochInstitute for Interfacial Engineering and Plasma Technology, University of Stuttgart, Stuttgart, Germany.
Torsten WalterBiomaterials Department, INNOVENT e. V., Jena, Germany.
Ralf WyrwaBiomaterials Department, INNOVENT e. V., Jena, Germany.
Matthias SchnabelrauchBiomaterials Department, INNOVENT e. V., Jena, Germany.
Malte SchmidtDepartment of Plastic Surgery and Burn Centre, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.
Maximilian KückelhausDepartment of Plastic Surgery and Burn Centre, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.
Marcus LehnhardtDepartment of Plastic Surgery and Burn Centre, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.
Tobias HirschDepartment of Plastic Surgery and Burn Centre, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.
Frank JacobsenDepartment of Plastic Surgery and Burn Centre, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro-generated soft tissue could provide alternate therapies for soft tissue defects. The aim of this study was to evaluate methacrylated gelatin/hyaluronan as scaffolds for soft tissue engineering and their interaction with human adipose-derived stem cells (hASCs). ASCs were incorporated into methacrylated gelatin/hyaluronan hydrogels. The gels were photocrosslinked with a lithium phenyl-2,4,6-trimethylbenzoylphosphinate photoinitiator and analyzed for cell viability and adipogenic differentiation of ASCs over a period of 30 days. Additionally, an angiogenesis assay was performed to assess their angiogenic potential. After 24 h, ASCs showed increased viability on composite hydrogels. These results were consistent over 21 days of culture. By induction of adipogenic differentiation, the mature adipocytes were observed after 7 days of culture, their number significantly increased until day 28 as well as expression of fatty acid binding protein 4 and adiponectin. Our scaffolds are promising as building blocks for adipose tissue engineering and allowed long viability, proliferation, and differentiation of ASCs.

Indexed as

adipose-derived stem cellsadipose tissuemethacrylationSoft tissue defects

Identifiers

PMID29318000
PMCPMC5753891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.