Evidence map›Paper›PMID 29317916›Full record

ArticleClinical epigenetics2018

Exposure to NO

Mary Prunicki, Laurel Stell, Deendayal Dinakarpandian, Mariangels de Planell-Saguer, Richard W Lucas, S Katharine Hammond, John R Balmes, Xiaoying Zhou, Tara Paglino, Chiara Sabatti and 2 more

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Association between air pollution and allergic upper respiratory diseases: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. The impact of particulate matter 2.5 on the risk of hepatocellular carcinoma: a meta-analysis.International archives of occupational and environmental health · 2022
    Pooled it
  3. Pooled it
  4. Early Life Exposure to Air Pollutants and Childhood Asthma.Current allergy and asthma reports · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Air pollution and alveolar health.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  13. Review
  14. Article
  15. Effect of air pollution on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Review
  16. Review
  17. Epigenome-wide association studies of allergic disease and the environment.The Journal of allergy and clinical immunology · 2023
    Review
  18. Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.The journal of allergy and clinical immunology. Global · 2023
    Article
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Mary PrunickiSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305 USA.ORCID 0000-0002-5511-8896
Laurel StellDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305 USA.
Deendayal DinakarpandianDepartment of Medicine, Stanford University, Stanford, CA 94305 USA.
Mariangels de Planell-SaguerDepartment of Medicine, Columbia University, New York, NY 10032 USA.
Richard W LucasSouthwest Environmental Institute, Phoenix, AZ 85087 USA.
S Katharine HammondSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720 USA.
John R BalmesSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720 USA.
Xiaoying ZhouSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305 USA.
Tara PaglinoSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305 USA.
Chiara SabattiDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305 USA.
Rachel L MillerDepartment of Medicine, Columbia University, New York, NY 10032 USA.
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305 USA.
Stanford University · USColumbia University · USArizona Christian University · USBerkeley Public Health Division · USUniversity of California, San Francisco · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
UC Berkeley/Stanford Children's Enviromental Health CenterP01ES022849 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HAMMOND, S KATHARINE · 2013 to 2018
$4.2M
Phenotyping/Epigenetic studies of PAH-associated Treg impairment in asthmaR01ES020926 · NIEHS · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2012 to 2016
$2.5M
Project 3: Ambient Pollutants/Bioaerosol Effects on Treg FunctionP20ES018173 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HAMMOND, S KATHARINE · 2010 to 2012
$895k
NIEHS NIH HHS P01 ES022849NIEHS NIH HHS P20 ES018173NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES020926NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

Background: DNA methylation of CpG sites on genetic loci has been linked to increased risk of asthma in children exposed to elevated ambient air pollutants (AAPs). Further identification of specific CpG sites and the pollutants that are associated with methylation of these CpG sites in immune cells could impact our understanding of asthma pathophysiology. In this study, we sought to identify some CpG sites in specific genes that could be associated with asthma regulation ( Results: Asthma was significantly associated with higher differentially methylated regions (DMRs) of the Conclusions: Short-term and long-term exposures to high levels of CO, NO

Indexed as

DNA MethylationAdolescentAsthmaCaliforniaCarbon MonoxideCpG IslandsEpigenesis, GeneticFemaleForkhead Transcription FactorsGene Expression RegulationGenetic Association StudiesHumansInterleukin-10IntronsMaleNitrogen DioxideCarbon MonoxideForkhead Transcription FactorsFOXP3 protein, humanIL10 protein, humanInterleukin-10Nitrogen DioxideParticulate MatterAmbient air pollutionEpigeneticsImmune systemRegulatory T cell

Identifiers

PMID29317916
PMCPMC5756438
OpenAlexW2782401531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.