Evidence map›Paper›PMID 29317847›Full record

ArticleJournal of pain research2018

Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes.

Lisa Lynn Dragic, Erica L Wegrzyn, Michael E Schatman, Jeffrey Fudin

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. A Study of the MTHFR Gene Prevalence in a Rural Tennessee Opioid Use Disorder Treatment Center Population.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lisa Lynn DragicCentral Arkansas Veterans Healthcare System, Little Rock, AR, USA.
Erica L WegrzynDepartment of Pharmacy, Albany Stratton VA Medical Center, Albany, NY, USA.
Michael E SchatmanResearch and Network Development, Boston Pain Care, Waltham, MA, USA.
Jeffrey FudinDepartment of Pharmacy, Albany Stratton VA Medical Center, Albany, NY, USA.
Albany Stratton VA Medical Center Albany · USCentral Arkansas Veterans Healthcare System · USTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of pharmacogenomics has become more prevalent over the past several years in treating many disease states. Several cytochrome P450 enzymes play a role in the metabolism of many pain medications including opioids and antidepressants. Noncytochrome P450 enzymes such as methylenetetrahydrofolate reductase (MTHFR) and catechol-

Indexed as

catechol-O-methyltransferaseCOMTdepressionmethyl tetrahydrofolate reductaseMTHFRpainpharmacogenetic

Identifiers

PMID29317847
PMCPMC5743122
OpenAlexW2776671338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.