Evidence map›Paper›PMID 29317827›Full record

ReviewJournal of multidisciplinary healthcare2018

Optimal management of Cogan's syndrome: a multidisciplinary approach.

Vittorio D'Aguanno, Massimo Ralli, Marco de Vincentiis, Antonio Greco

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of multidisciplinary healthcare, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Moyamoya Vasculopathy with Atypical Cogan's Syndrome: A Case Report.Archives of clinical and medical case reports · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Cogan syndrome: a case report and review of the literature.Digital journal of ophthalmology : DJO · 2023
    Review
  7. Article
  8. Aortitis Secondary to Cogan's Syndrome: A Rare Cause of Fever of Unknown Origin.European journal of case reports in internal medicine · 2022
    Article
  9. Article
  10. Review
  11. [Immune-mediated sensorineural hearing loss: prevalence and treatment strategies].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020
    Review
  12. Article
  13. Review
  14. Audiovestibular Symptoms in Systemic Autoimmune Diseases.Journal of immunology research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vittorio D'AguannoDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
Massimo RalliDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Marco de VincentiisDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Antonio GrecoDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism. CS is considered as an autoimmune- or immune-mediated disease supported mainly by the beneficial response to corticosteroids. Using well-developed assays, antibodies to inner ear antigens, anti-Hsp70, and antineutrophil cytoplasmic antibodies were found to be associated with CS. Corticosteroids represent the first line of treatment, and multiple immunosuppressive drugs have been tried with variable degrees of success. Tumor necrosis factor-alpha blockers and other biological agents are a recent novel therapeutic option in CS. Cochlear implantation is a valuable rescue surgical strategy in cases with severe sensorineural hearing loss unresponsive to intensive and/or innovative immunosuppressive regimens.

Indexed as

autoimmunityCogan’s syndromehearing lossmultidisciplinary approach

Identifiers

PMID29317827
PMCPMC5743115
OpenAlexW2781253814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.